Abstract P371: Prevalence of Cardiometabolically Healthy and Cardiometabolically Unhealthy Peruvians by Body Mass Index Categories: The CRONICAS Cohort Study
Background: Obesity is associated with a number of cardiometabolic risk factors. However, despite increased adiposity, some obese individuals display normal metabolic features. Conversely, individuals with normal weight can display metabolically unhealthy features. These profiles have not been researched in Latin American populations. We aimed to characterize cardiometabolic status by body mass index (BMI) status with emphasis on unhealthy cardiometabolic profile among normal weight individuals, and healthy cardiometabolic profile among overweight and obese.
Methods: The CRONICAS Cohort is a an age- and sex-matched population-based study across four different geographical settings: Lima (Peru’s capital, urban), Tumbes (lowland, semirural), Puno rural and Puno urban (both high altitude). Individuals were classified into two groups: cardiometabolically healthy with (0-1 abnormality) or cardiometabolically unhealthy (≥2 abnormalities). The conditions for cardiometabolic assessment included components of the metabolic syndrome, high-sensitivity C-reactive protein, and insulin resistance.
Results: A total of 3088 individuals, mean age 55.6 (SD±12.6) years, 51.3% females, had all measurements for this analysis. Of these, 889 subjects (28.8%), 1359 (44.1%) and 838 (27.1%) had normal weight, overweight and obese, respectively. Among normal weight individuals, 43.1% were cardiometabolically unhealthy (figure), and age ≥65 years, female, and highest wealth index groups were more likely to have this pattern. In contrast, only 16.0% of overweight and 3.6% of obese individuals were cardiometabolically healthy. In the combined overweight/obese group, compared to Lima, rural and urban sites in Puno were more likely of having the cardiometabolically healthier profile.
Conclusions: Our results indicate a high prevalence of cardiometabolic abnormalities in Peru, specifically among normal weight individuals. Prevention programs to address cardiovascular risk need to include people of normal weight.
Author Disclosures: C.P. Benziger: None. A.`. Bernabe-Ortiz: None. R.H. Gilman: None. W. Checkley: None. L. Smeeth: None. G. Malaga: None. J. Miranda: None.
- © 2015 by American Heart Association, Inc.