Abstract P326: Nut Consumption is Inversely Associated with Mortality in a Mediterranean Population: Prospective Results from The MOLI-SANI Study
Introduction: Nut intake has been associated with reduced inflammatory status, cardiovascular disease (CVD) and mortality. Poor evidence exists on the likely benefits from nut intake for subjects at different CVD risk and the role of inflammation in accounting for such an association.
Hypothesis: We assessed the hypothesis that nut intake is associated with total mortality in a Mediterranean population at different CVD risk.
Methods: Population-based prospective investigation on 19,386 subjects apparently free from CVD and cancer disease enrolled in the MOLI-SANI study. Food intake was recorded by the EPIC food frequency questionnaire. C-reactive protein, leukocyte and platelet counts and the neutrophil/lymphocyte ratio were used as biomarkers of low-grade inflammation. Hazard ratios and 95%CI were calculated using multivariable Cox-proportional models.
Results: At the end of follow-up (median 4.2 years), 334 all-cause deaths occurred. As compared to subjects who never ate nuts, rare intake (≤2 times per month) was associated with a significant reduction in the risk of overall death (HR=0.70; 0.55-0.89 in the multivariable model). At highest intakes a greater protection was observed (HR=0.55; 0.33-0.92 for those having nuts ≥8 times a week), the maximal effect reaching a plateau.
Nut intake (vs no intake) appeared to convey a higher protection for individuals poorly adhering to a Mediterranean diet (MD) and slightly for those with hypertension. The impact on CVD deaths was limited to an inverse not significant trend (HR=0.85; 0.56-1.30). Biomarkers of low-grade inflammation only marginally accounted for the observed associations.
Conclusions: Nut intake is associated with reduced total mortality in a general population free from major chronic diseases. The protection was stronger in individuals with a low adherence to MD, while it was similar in high or low CVD risk groups that appeared to benefit from even a modest consumption of nuts. Low-grade inflammation only marginally explained the observed relationship.
Author Disclosures: M. Bonaccio: None. A. Di Castelnuovo: None. A. de Curtis: None. S. Costanzo: None. F. Bracone: None. M. Persichillo: None. M. Donati: None. G. de Gaetano: None. L. Iacoviello: None.
- © 2015 by American Heart Association, Inc.