Abstract P314: Plasma Polyunsaturated Fatty Acids and Fish Oil Intake in Relation to Pulse Wave Velocity - The AGES Reykjavik Study
Introduction: Higher intake and circulating polyunsaturated fatty acids (PUFAs) are associated with lower CVD risk. PUFAs might influence vascular health via reducing arterial stiffness, resulting in a better CVD risk profile, but investigations of this association in the general population are limited.
Hypothesis: We assessed the hypothesis that higher levels of plasma phospholipid long chain n-3 PUFAs (eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA)), and long chain n-6 PUFAs (linoleic acid (LA) and arachidonic acid (AA)) are associated with lower arterial stiffness. We also assessed the hypothesis that higher dietary intake of fish oil in early life (ages 14 to 19), mid-life (ages 40 to 50) and in old age (ages 69 to 96, study baseline) is associated with lower arterial stiffness.
Methods: We used longitudinal data from a subgroup of AGES-Reykjavik Study participants (n=501, 75.0±4.96 years, 46% men), a population-based study of community dwelling older adults. Plasma phospholipid PUFAs (gas chromatography) were determined at baseline, and recalled fish oil intake was assessed across the lifetime using a validated food frequency questionnaire. Arterial stiffness was determined as carotid-femoral pulse wave velocity (cf-PWV) using an electrocardiogram after a mean follow-up of 5.2±0.3 years subsequent to study baseline. Regression coefficients (and 95% confidence intervals), adjusted for demographics, follow-up time, risk factors, and serum vitamin D were calculated by linear regression.
Results: Each SD increment of total n-3 PUFAs, EPA and DHA in plasma was associated with lower cf-PWV. In contrast, each SD increment of total n-6 PUFAs and LA was associated with higher cf-PWV. No relationships were observed for DPA, ALA or AA. Regular dietary consumption of fish oil (5-6 times a week or daily) was not associated with cf-PWV at any point in life.
Conclusions: In conclusion, our results show that higher plasma levels of long-chain n-3 PUFAs may result in less arterial stiffness and therein may reduce CVD risk in older persons, and suggest a positive association between n-6 PUFA and arterial stiffness. Future larger prospective studies are warranted to clarify the opposing associations between n-3 and n-6 PUFAs with cf-PWV and provide insight into mechanisms by which PUFAs influence vascular health.
Author Disclosures: I. Reinders: None. R.A. Murphy: None. X. Song: None. G.F. Mitchell: None. M. Visser: None. M. Cotch: None. M.E. Garcia: None. L.J. Launer: None. G. Eiriksdottir: None. V. Gudnason: None. T.B. Harris: None. I.A. Brouwer: None.
- © 2015 by American Heart Association, Inc.