Abstract P312: Macronutrients Intake and Incident Frailty in the Elderly: A Prospective Cohort Study in Spain
Background and objective: Higher protein consumption has been independently associated with a lower risk of incident frailty in older women. Nevertheless, no previous prospective study has focused on the potential effects of other macronutrients on the risk of frailty in both men and women. This study examined prospectively the association between dietary macronutrients intake and incident frailty in community-dwelling older adults in Spain.
Methods: A prospective cohort with 1,822 community-dwelling individuals aged ≥60 years was recruited in 2008-2010 and followed through 2012. At baseline, nutrient intake was measured using a validated computerized face-to-face diet history. In 2012, individuals were contacted to detect incident frailty. According to the Fried's criteria, frailty was defined by the presence of at least three of the following criteria: low physical activity, slowness, unintentional weight loss (10 pounds or more in a year), muscle weakness (lowest quintile of strength within groups defined by sex and BMI), and self-reported exhaustion. Analyses were performed using logistic regression and adjusted for the main confounders, including total energy intake using the nutrient residual model.
Results: During 3.5 years of follow-up, 132 persons with incident frailty were identified. When the amount of energy from animal protein intake was substituted for the same amount of energy from carbohydrates, the ORs (95% CI) of frailty by quartiles of animal protein intake were 1.00, 0.74 (0.43-1.28), 0.54 (0.31-0.96), and 0.52 (0.28-0.96); p for trend 0.019. When energy from monounsaturated fatty acids intake was substituted for the same amount of energy from carbohydrates, the results by quartiles of monounsaturated fatty acids intake were: 1.00, 0.59 (0.32-1.08), 0.50 (0.26-0.96), and 0.44 (0.22-0.88); p for trend 0.025. No association was found between intake of vegetal proteins, saturated fats, long-chain ω-3 fatty acids, alfa-linolenic acid, linoleic acid, simple sugars, or polysaccharides and the risk of frailty.
Conclusion: Animal protein and monounsaturated fatty acids intake were inversely associated with incident frailty in the elderly. Substituting animal protein and monounsaturated fatty acids for carbohydrates in the diet may be an appropriate strategy to reduce frailty in this population.
Founding: FP7-HEALTH-2012-Proposal No: 305483-2 (FRAILOMIC Initiative), FIS grants PI11/01379 and PI13/288 (Ministry of Health of Spain).
Author Disclosures: P. Guallar-Castillon: None. H. Sandoval-Insausti: None. R.F. Pérez-Tasigchana: None. E. López-García: None. E. García-Esquinas: None. F. Rodríguez-Artalejo: None.
- © 2015 by American Heart Association, Inc.