Abstract P311: Tree Nut Consumption is Inversely Associated With Subclinical Atherosclerosis: The NHLBI Family Heart Study
Background: Epidemiologic and clinical trial data have demonstrated beneficial effects of nut consumption on cardiovascular risk factors and mortality. However, little is known about the association of nut consumption and subclinical atherosclerosis in the general population.
Objective: To test the hypothesis that tree nut consumption is associated with a lower risk of subclinical atherosclerosis.
Methods: We determined risk factors and tree nut consumption in a cross-sectional sample of 2297 participants from the NHLBI Family Heart Study without known coronary heart disease. Nut consumption was determined from a Food frequency questionnaire (FFQ) and participants were categorized into 3 groups according to their nut consumption (never/rare, less than once/week, and >= 1 time/week). The primary outcome was prevalent coronary calcification, defined as coronary artery calcium (CAC) score > 100 Agatston units (AU). We fitted generalized estimating equations (GEE) to calculate the prevalence odds ratios of coronary calcification.
Results: Mean age was 58.1 years and 44.8% of participants were male. Mean consumption of tree nuts was 1-3 servings per month. Across consecutive categories of nut consumption, odds ratios (95% CI) for prevalent CAC were 1.0 (reference) 0.94 [0.68 - 1.3], and 0.74 [0.52-1.09] after adjustment for age, sex, hypertension, hyperlipidemia, diabetes, BMI, current smoking, current alcohol use, physical activity, income, and field center (p for trend= 0.13).
Conclusion: Our data are consistent with an inverse association of tree nut consumption with subclinical atherosclerosis measured by coronary artery calcification.
Author Disclosures: O.K. Onuma: None. A. Petrone: None. J. Robbins: None. R.C. Ellison: None. J.J. Carr: None. D.K. Arnett: None. S.C. Hunt: None. J.M. Gaziano: None. L. Djousse: None.
- © 2015 by American Heart Association, Inc.