Abstract P297: Alcohol Consumption and Cardiac Biomarkers
Background: Excess alcohol consumption can lead to myocardial dysfunction. However, whether novel cardiac biomarkers tests can detect subclinical myocardial damage and wall stress in asymptomatic populations exposed to alcohol is currently unknown.
Objective: To characterize the association of alcohol consumption with subclinical myocardial damage, as assessed by a novel highly sensitive assay for cardiac troponin T (hs-cTnT) and wall stress, as assessed by N-terminal pro-brain natriuretic peptide (NT-proBNP).
Methods: Using data from the community-based ARIC Study we examined the cross-sectional association of categories of self-reported alcohol consumption with cardiac biomarkers among 10,381 individuals without cardiovascular disease (1990-92). We also examined the prospective association of alcohol consumption with 6-year change in cardiac biomarkers in a subset of participants (n=8,972 for hs-cTnT and n=9,060 for NT-proBNP), who had each biomarker measured at two time points. Incident elevated NT-proBNP was defined as ≥300 pg/mL.
Results: Cross-sectionally, compared to those drinking ≤ 1 drink/week, those drinking moderately (2-7 drinks/wk) and high (8+ drinks/wk) amounts of alcohol had significantly lower levels of hs-TnT (Figure). We found no significant association in the prospective analyses of alcohol and hs-cTnT. In contrast, high alcohol consumption was associated with elevated NT-proBNP (Figure). Prospectively, compared to those drinking ≤ 1 drink/week, those drinking 8-14 drinks/week and 15+ drinks/week had increased risk of incident elevation of NT-proBNP RRR=1.77(95%CI 1.19-2.63) and RRR=2.83 (95%1.66-4.85), respectively.
Conclusions: We found a weak protective effect of moderate and high alcohol consumption on myocardial damage. In contrast, opposite effect was observed for subclinical wall stress. These findings are consistent with the observed elevated risk of hypertension and stroke with alcohol consumption.
Author Disclosures: M. Lazo: B. Research Grant; Significant; Received grant from ABMRF. Y. Chen: None. J.W. McEvoy: None. C. Ndumele: None. S. Konety: None. A. Sharrett: None. C.M. Ballantyne: B. Research Grant; Modest; Grant support from Roche Diagnostics. C. Other Research Support; Modest; Reagents for the high sensitivity cardiac troponin assays were donated by Roche Diagnostics.. E. Selvin: None.
- © 2015 by American Heart Association, Inc.