Abstract P294: 25-OH Vitamin D concentration and All-Cause Mortality Following Coronary Catheterization in Alberta, Canada.
Background: While vitamin D deficiency has been identified as a potential risk marker for cardiovascular disease, little information exists on whether it is associated with outcomes following coronary interventions (e.g. angioplasty).
Objective: To examine the association between total 25-OH vitamin D concentration and all-cause mortality among patients undergoing coronary catheterizations in Calgary and Edmonton Alberta for the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH).
Methods: Provincial laboratory data containing the first measurement of 25-OH vitamin D prior to coronary catheterization was merged to APPROACH covariate and outcome data from 2009-2013, defining a sub-cohort of 3358 participants. Data from the 2011 National Household Survey was merged by postal code to provide neighborhood level socioeconomic data. Multiple logistic regression was used to examine the association between 25-OH vitamin D and all-cause mortality.
Results: There were a total of 294 deaths over a median follow-up of 2.6 years. Total 25-OH vitamin D was inversely associated with odds of all-cause mortality after adjusting for age, sex, smoking and BMI. (bottom quintile (≤42 nmol/L) vs top quintile (≥94 nmol/L): OR = 2.3, 95% CI: 1.6-3.5, p for trend < 0.01). This association was slightly attenuated (OR = 2.0, p for trend < 0.01) after adjusting for baseline renal disease, hypertension, hyperlipidemia, type 2 diabetes, family history of CHD, prior MI, Duke severity score, and neighborhood socioeconomic variables (% immigrants, % non-official language speakers, % with postsecondary education, % employed, median household income). The association was slightly attenuated with increasing time between vitamin D measurement and catheterization (p for interaction = 0.01).
Conclusions: In a population of individuals who underwent coronary catheterization in Alberta, Canada, pre-catheterization 25-OH vitamin D concentration was inversely associated with post-catheterization mortality, even after adjusting for major confounders, mediators and neighborhood-level socioeconomic factors. Vitamin D deficiency might therefore provide additional information on mortality risk in a population undergoing invasive cardiac procedures.
Author Disclosures: L. de Koning: B. Research Grant; Modest; MSI Foundation of Alberta. M. Gerling: None. M. Zhang: None. C. Naugler: None. M. Knudtson: None.
- © 2015 by American Heart Association, Inc.