Abstract P290: Tai Chi Downregulates Pro-inflammatory Cytokines in Women With Increased Cardiometabolic Risk
Authors: Jo Lynne Robins, PhD, RN; Assistant Professor, Virginia Commonwealth University School of Nursing & Jamie L. Sturgill, PhD; Assistant Professor, Virginia Commonwealth University School of Nursing.
Objectives: To examine the effects of a unique tai chi intervention designed to impact inflammatory factors associated with cardiometabolic risk (CMR) in women with early indicators of risk for cardiovascular disease (CVD).
Methods: A randomized clinical trial was conducted in women with increased CMR, as evidenced by increased abdominal adiposity and a family history of CVD. To measure multiple cytokines/chemokines/growth factors, cryopreserved plasma samples were batch-processed using commercially prepared 17-plex kits with a Bio-Plex Pro™ (BioRad, Inc.) magnetic bead system (intra-assay variability < 5%, interassay variability < 9 %, cross-reactivity < 1.0%).
Findings: In a sample of 63 women, there were no significant differences in cytokine/growth factor levels at baseline. However, following the 8-week tai chi intervention, there were statistically significant decreases in the intervention vs. control groups in five cytokines/growth factors: interleukin (IL)-6, IL-7, IL-8, granulocyte colony stimulating factor (GCSF), and tumor necrosis factor (TNF), indicating a decrease in signaling associated with systemic inflammation (Table 1).
Conclusions: This study contributes important insights into the potential benefits and mechanisms of tai chi. Perhaps over a longer period of time, changes in cytokines/growth factors affecting inflammatory signaling may result in changes in other biological outcomes. Ultimately, this line of research may lead to effective strategies for reducing the systemic inflammation associated with CMR at earlier points in the CVD trajectory.
Table 1. Statistically Significant Cytokines/Growth Factors after 8-weeks Control or Intervention Cytokine Control Mean (SE) Intervention Mean (SE) p-value IL-6 15.36 (2.8) 7.44 (0.83) 0.012
IL-7 14.24 (1.20) 17.78 (8.03) 0.02
IL-8 22.64 (2.58) 14.04 (16.51) 0.005
GCSF 69.99 (8.26) 40.47 (6.07) 0.001
TNF 38.40 (4.38) 23.46 (3.19) 0.018
Author Disclosures: J. Robins: None. J.L. Sturgill: None.
- © 2015 by American Heart Association, Inc.