Abstract P273: Leisure-Time Physical Activity and Mortality in the Northern Manhattan Study
Introduction: Leisure-time physical activity (LTPA) provides multiple health benefits, including a reduction in mortality. Fewer studies however have examined whether the health benefits of LTPA are modified by other risk factors for mortality, such as obesity.
Methods: We collected baseline socio-demographics and cardiovascular risk factor data in a population-based, tri-ethnic prospective cohort (Northern Manhattan Study) using self-report and objective measures for vital signs and anthropometrics. The primary exposure was self-reported leisure-time physical activity and the outcomes of this analysis were total, vascular, and non-vascular deaths. Leisure-time physical activity was defined categorically as any activity versus none, and by quartiles of the Metabolic equivalents (MET)-score (weighted by total activity and intensity).We calculated the association of LTPA with the risk of mortality using multi-variable Cox-proportional hazards models, and examined interactions between leisure-time physical activity and body mass index (BMI) <30 vs ≥30.
Results: A total of 3298 participants were enrolled (mean age 69, 52% Hispanic, 63% women) and followed over a mean of 11.8 years with 1589 total deaths (641 vascular, 819 non-vascular). In multi-variable models, compared to no LTPA, any activity (adjusted HR 0.84, 95%CI 0.75-0.94) and the upper quartile of the MET-score (adjusted HR 0.79, 95%CI 0.69-0.91) were associated with lower risk of all-cause mortality. There were similarly significant findings for non-vascular deaths, but the results for vascular death did not reach statistical significance (any activity versus none HR 0.90, 95%CI 0.76-1.08; upper quartile of the MET-score HR 0.89, 95%CI 0.71-1.10). We found that the effects of LTPA for risk of all-cause and vascular mortality were modified by obesity (all p for interactions <0.05). Any LTPA versus none was associated with lower risk of all-cause mortality (adjusted HR 0.77, 95%CI 0.68-0.88) and vascular death (adjusted HR 0.79, 95%CI 0.65-0.97) only among those with BMI<30, and not among those with a BMI≥30.
Discussion: We found that the survival benefit of LTPA depends on BMI, with no definite evidence of a benefit among the obese. The health benefits of exercise should be considered in the context of the ameliorating other cardiovascular disease risk factors.
Author Disclosures: J.Z. Willey: B. Research Grant; Modest; NINDS K23073104. Y.P. Moon: None. A. Sherzai: None. P. Gervasi-Franklin: None. K. Cheung: B. Research Grant; Significant; NHLBI R01 HL 111195. R.L. Sacco: B. Research Grant; Significant; NINDS R37 NS 29993. M.S.V. Elkind: B. Research Grant; Significant; NINDS R37 NS 29993.
- © 2015 by American Heart Association, Inc.