Abstract P269: Restricted Spirometry is Associated With Cardiovascular Risk in Asymptomatic Adults Independent of the Confound Effect of the Level of Physical Activity and Fitness
Introduction: Restricted spirometry has been associated with cardiovascular disease. Whether the level of physical activity and fitness is a confounder in this relationship was not investigated. Hypothesis: We tested the hypothesis that restricted spirometry is associated to cardiovascular risk despite the accelerometer-based physical activity and physical fitness levels. Objective: To investigate the association between restricted spirometry and cardiovascular risk factors in asymptomatic adults, independent of the level of physical activity and fitness. Secondarily, we assessed the prevalence of this spirometric abnormality in a sample of Brazilians. Methods: A total of 374 participants (41 ± 14 years) underwent a spirometry test. Restricted spirometry was defined as FEV1/FVC > 70% and FVC < 80% of the predicted values. After demographic, anthropometric and cardiovascular risk assessment, we evaluated body composition (bioimpedance), isokinetic muscle function, postural balance on a force plate, cardiopulmonary exercise testing and six-minute walk test. Physical activity in daily life was measured by means of 7 days of monitoring using a triaxial accelerometer. Physical inactivity was defined as less than 150 min/wk of moderate to vigorous physical activity. Multivariate logistic regression was adjusted by age, sex, race, level of education, cardiovascular risk factors, physical inactivity, body composition, peripheral muscle function, postural balance and cardiorespiratory fitness. Results: The prevalence of restricted spirometry was 10%. After multivariate logistic regression, variables that remained as significant predictors of restricted spirometry were hypertension (odds ratio, 17.5: 95% confidence interval, 1.65 to 184.8), smoking (11.6: 1.56 to 87.5), physical inactivity (8.1: 1.43 to 46.4) and center of pressure during bipedal assessment on the force plate (1.34: 1.05 to 1.71). Conclusion: Restricted spirometry was a common finding in asymptomatic adults. Cardiovascular risk factors, especially hypertension, smoking and physical inactivity, were strictly associated with this spirometric abnormality, independent of the confound effect of the level of physical activity and fitness. Thus, additional research is needed to better understand the etiology of restricted spirometry and to design preventive strategies.
Author Disclosures: E.F. Sperandio: None. R.L. Arantes: None. A.C. Matheus: None. R.P. Silva: None. V.T. Lauria: None. M. Barboza: None. M. Romiti: None. A.R.T. Gagliardi: None. V.Z. Dourado: None.
- © 2015 by American Heart Association, Inc.