Abstract P255: Body Mass index, C-Reactive Protein and Mortality among Coronary Artery Disease Patients
Background: The association between BMI and mortality is debated among coronary artery disease (CAD) patients. C-reactive protein (CRP), a harmful predictor for CAD, may be linked with the above association.
Objectives: The present study was to investigate the single and joint associations of BMI and CRP with mortality.
Methods: The study included 1980 Chinese CAD patients who were 40-85 years of age in the Guangdong Coronary Artery Disease Cohort. Cox proportional hazards regression models were used to estimate the association of BMI and serum CRP with death risk.
Results: During a median follow-up of 3.1 years, 141 deaths were recorded, 110 were due to cardiovascular disease (CVD). After adjustment of major CVD risk factors, there was a J-shaped association between BMI and all-cause and CVD mortality, and a positive association between CRP and mortality. The J-shaped association of BMI with mortality was present among patients with elevated CRP (≥3.0 mg/L). Compared with overweight (BMI 24-27.9 kg/m2) patients with normal CRP concentration (<3.0 mg/L), obese patients (BMI≥28 kg/m2) with elevated CRP concentration had a 3.41-fold risk of all-cause mortality (95% CI 1.49-7.80) and a 3.50-fold risk of CVD mortality (1.40-8.75), lean patients (BMI<24 kg/m2) with elevated CRP concentration had a 2.54-fold risk of all-cause mortality (1.36-4.74) and a 2.36-fold risk of CVD mortality (1.19-4.70). When we did an additional analysis among patients who never smoked, the J-shaped association of BMI with all-cause and CVD mortality was confirmed among non-smokers. When we excluded the participants who died during the first year of follow-up (n= 61), the J-shaped association did not change.
Conclusions: The present study found a J-shaped association of BMI with all-cause and CVD mortality, and a positive association between serum CRP and all-cause and CVD mortality 2 among Chinese CAD patients. This J-shaped association was only observed among patients with elevated CRP concentration. For patients with normal CRP concentration, the risk of death increased with BMI levels.
Author Disclosures: D. Ding: None. M. Wang: None. D. Su: None. C. Hong: None. X. Li: None. Y. Zhang: None. G. Hu: None. W. Ling: None.
- © 2015 by American Heart Association, Inc.