Abstract P248: Measures of Overall and Central Obesity and Cardiovascular Disease Risk Factors Among US Hispanic / Latino Adults: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Background: US Hispanics/Latinos have a high prevalence of obesity and related comorbidities. Few studies have compared different obesity measures and their associations with cardiovascular disease (CVD) risk factors in US Hispanic/Latino adults.
Methods: We examined associations of six obesity measures (body mass index [BMI], fat mass index, and body fat percentage, waist circumference, waist-to-hip ratio [WHR], and waist-to-height ratio) with metabolic traits and CVD risk factors (hypertension, dyslipidemia and diabetes), among 9835 women and 6580 men from the HCHS/SOL, a population-based cohort of Hispanics/Latinos age 18-74 years from four US cities.
Results: BMI was moderately correlated with WHR (r=0.37 in women; r=0.58 in men) and highly correlated with other obesity measures (r≥0.88 in women; r≥0.87 in men). The metabolic trait correlating most strongly with obesity measures was HOMA-IR (r≥0.34 in women; r≥0.45 in men), followed by triglycerides (r≥0.27 in women; r≥0.29 in men) and HDL-cholesterol (r≤-0.27 in women; r≤-0.24 in men), with similar r estimates for each obesity measure. In multivariable-adjusted analyses, prevalence ratios (PRs) of CVD risk factors differed across subgroups defined by BMI and other obesity measures, with a highest PR of diabetes in overweight/obese (BMI≥25 kg/m2) women (6.81 [3.96, 11.70]) and men (3.92 [95%CI 2.23, 6.90]) with abnormal WHR(≥0.85 in women/≥0.90 in men) (Table). Notably, in the normal-weight group (18.5≤BMI<25.0 kg/m2), abnormal WHR was associated with increased PRs of hypertension (1.43 [1.10, 1.86] in women; 1.76 [1.30, 2.37] in men), diabetes (4.15 [2.32, 7.44] in women; 3.10 [1.67, 5.74] in men), and dyslipidemia (1.59 [1.24, 2.03] in women; 1.50 [1.24, 1.82] in men).
Conclusions: BMI and other overall and central obesity measures performed similarly in their degree of associations with CVD risk factors in US Hispanics/Latinos. However, BMI and other obesity measures (such as WHR) assessed in combination, are useful to identify individuals at high risk for CVD.
Author Disclosures: Q. Qi: None. G. Strizich: None. D. Hanna: None. R.A. Espinoza-Giacinto: None. S.F. Castañeda: None. D. Sotres-Alvarez: None. A. Pirzada: None. M.M. Llabre: None. N. Schneiderman: None. L. Aviles-Santa: None. R.C. Kaplan: None.
- © 2015 by American Heart Association, Inc.