Abstract P247: The CHANGE Study: Comprehensive Primary Pulmonary Hypertension Assessment & Nutritional manaGEment
Primary Pulmonary Hypertension (PPH) characterizes systolic pulmonary arterial pressures greater than 40 mm Hg with no known underlying disease or condition causing the elevation. Limited treatments are available for PPH, with the most recent life expectancy estimates remaining below 7 years after diagnosis. In this study, we assessed whether obesity contributes to PPH and the impact of lifestyle modification & weight loss on pulmonary pressures.
We recruited 30 volunteers with PPH and 30 healthy controls with normal pulmonary pressures. We assessed participants’ Body Mass Index (BMI) and pulmonary pressures through a 2D echocardiogram study. The PPH population was observed to have a significantly greater BMI, 36.0 kg/m2, than the control participants, 28.9 kg/m2 (p<0.0001). 100% (30 out of 30) PPH participants were observed to have a BMI greater than 30 kg/m2, classifying them as at least mildly obese.
In the intervention phase of this study, participants were prescribed a two month DASH diet & lifestyle intervention, with the goal of a clinically significant 5% weight loss from baseline. Subsequently, we reassessed participants’ BMI and pulmonary arterial pressures. PPH participants who achieved at least a 5% weight loss while adhering to the DASH diet were observed to have an average 11.8 mm Hg reduction in pulmonary pressures, representing an average 25.3% decrease in pulmonary pressures. A marginal reduction in pulmonary pressures was observed in those who did not achieve the targeted 5% weight loss (2.8 mm Hg). A very strong, positive correlation was observed between the % weight loss and the % reduction in pulmonary pressures (r=0.9225, p<0.0001). 100% of PPH participants (29 out of 29) who achieved any degree of weight loss had a reduction in pulmonary pressures (Figure 1).
The results of this study suggest that obesity may be an important mechanism contributing to PPH. A lifestyle change resulting in a 5% weight loss, employing the DASH diet, could be examined as a therapeutic avenue in the future for PPH patients.
Author Disclosures: A.K. Pandey: None.
- © 2015 by American Heart Association, Inc.