Abstract P245: Sex-Specific Interaction Between Adiposity and Cellular Adhesion: The Multi-Ethnic Study of Atherosclerosis (MESA) Study
Background: Obesity is associated with diabetes, atherosclerosis, and inflammation. At the cellular level, how excess adiposity promotes atherogenesis is not fully understood. One of the pathways involves secretion of adipokines that stimulate endothelial dysfunction and subsequent atherogenesis by increasing endothelial permeability and leukocyte recruitment through increased expression of the adhesion molecules. However, the relationship of adiposity to adhesion molecules that promote atherosclerosis is largely unknown.
Methods: Linear regression models were used to assess the sex-specific associations of cellular adhesion molecules (P- and L-selectin, ICAM-1, VCAM-1, and HGF) and adiposity in 5,971 adults sampled at Exams 2 and 3 of the Multi-Ethnic Study of Atherosclerosis (MESA) study. Adiposity measures included body mass index (BMI), waist-to-hip-ratio (WHR), and CT measures of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT).
Results: The mean age of the cohort was 62 years old and 53% (3165 out of 5,971) were female. Overall, mean levels of P-selectin were lower in females compared to males, whereas L-selectin levels were higher in females (p <0.001). In multivariable models adjusting for age, race/ethnicity, and traditional cardiovascular risk factors, HGF was positively associated with BMI, WHR, and VAT in both males and females (see Table), and P-selectin with WHR and VAT in males. However, VCAM-1 was negatively associated with VAT in females but not males.
Discussion: Our results showed the relation of adiposity to cellular adhesion proteins generally does not vary across sex and adiposity measures. However, a novel sex-specific association between VCAM-1 and P-selectin with VAT suggests the relationship between adiposity and cellular adhesion proteins may in some instances be modified by sex and the measure used to assess adiposity.
Author Disclosures: M.J. Christoph: None. M.A. Allison: None. J.S. Pankow: None. P.A. Decker: None. P.S. Kirsch: None. M.Y. Tsai: None. M.M. Sale: None. M. de Andrade: None. H. Sicotte: None. W. Tang: None. N.Q. Hanson: None. C. Berardi: None. C.L. Wassel: None. N.B. Larson: None. S.J. Bielinski: None.
- © 2015 by American Heart Association, Inc.