Abstract P240: Iq’Mik Smokeless Tobacco Use And Cardio-Metabolic Risk Factors Among Yup’Ik Alaska Native People
Introduction: The traditional lifestyle of Yup’ik Alaska Native people, including a diet high in marine-based foods and daily physical activity, may be cardio-protective. However iq’mik, a traditional form of smokeless tobacco used by >50% of Yup’ik adults, could increase cardio-metabolic (CM) risk.
Objective: Our objective was to characterize the associations between iq’mik use and CM risk factors (low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], triglycerides [TG], blood glucose [BG], systolic blood pressure [SBP], diastolic blood pressure [DBP], heart rate [HR] and body mass index [BMI]).
Methods: We analyzed a cross-sectional sample of Yup’ik adults (n=874). Current iq’mik use, demographic and lifestyle data were collected through interviews. Fasting blood samples were collected to measure LDL-C, HDL-C, TG and BG. SBP, DBP, HR and BMI were obtained by physical exam.
We characterized the association between current iq’mik use and continuous CM risk factor measures both unadjusted for lifestyle and adjusted for lifestyle using two approaches, adjustment for: A) measures of Yup’ik lifestyle and B) a propensity score representing the conditional probability of using iq’mik.
Findings: Current iq’mik use was significantly associated with increased HDL-C levels and inversely associated with TG, BG, HR, and BMI (Table). However, after adjusting for lifestyle by either method, associations were attenuated, only BG remaining inversely associated with current iq’mik use (Table).
Conclusions: Iq’mik use was associated with cardio-protective measures when not adjusted for Yup’ik lifestyle factors. After adjusting for aspects of Yup’ik lifestyle, the inverse association between iq’mik use and BG remained, raising additional research questions about physiologic mechanisms.
Author Disclosures: T.K. Ryman: None. M.A. Austin: None. S. Hopkins: None. J. Philip: None. S.A.A. Beresford: None. B. Thompson: None. K.E. Thummel: None. B.B. Boyer: None.
- © 2015 by American Heart Association, Inc.