Abstract P232: The Relationship Between Lifestyle Factors and Cardiovascular Disease Risk in Hiv+ Adults
Introduction: HIV+ adults used to have markedly decreased life expectancy. Now, HIV is a manageable chronic disease and HIV+ adults are at risk for clinical CVD due to multiple physiological risk factors. Lifestyle factors may contribute to this risk and yet little is known about the influence of exercise, stress, and medication adherence on the CVD risk in HIV+ adults. Therefore, we sought to examine the associations over time among exercise, stress, medication adherence and CVD risk and hypothesized that they would be associated with the 30-year predicted risk of developing CVD in HIV+ adults.
Methods: Seventy HIV+ adults taking antiretroviral therapy (ART) were enrolled. Participants completed anthropomorphic measures, one-week exercise diary, Perceived Stress Scale, and consented to medical chart abstraction. Participants returned in one year and completed the same assessments. Cardiovascular risk was calculated using the Framingham 30-year risk models. We used generalized estimating equations to evaluate the association between lifestyle factors and CVD risk.
Results: Participant’s average age at baseline was 48.6 ± 8.4 years, 35 (50%) were male, 58 (83%) were African-American. At baseline, participants exercised 5.0 ± 5.7 hours per week, had a perceived stress scale score of 17.8, and were adherent to ART. One year later they exercised 7.3 ± 6.4 hours per week, had an average perceived stress scale score of 17.3, and were adherent to ART. Using data from two time points exercise, stress, and medication adherence were associated with 30-year lipid-based (Wald χ2 =9.5, p=0.02) and 30-year BMI-based (Wald χ2 =14.2, p<0.01) predicted CVD risk.
Conclusion: Lifestyle factors are significantly associated with CVD risk in HIV+ adults. Perceived stress was negatively associated with CVD risk with indicating that as stress increased, CVD risk decreased. This surprising finding indicates that more work is necessary to better understand the relationship between lifestyle factors and cardiovascular disease risk in HIV+ adults.
Author Disclosures: A.R. Webel: None. A. Sattar: None. C.T. Longenecker: None. N.J. Schreiner: None. R. Josephson: None.
- © 2015 by American Heart Association, Inc.