Abstract P228: Cardiovascular Risk Profiles and the 10-Year Risk of Atherosclerotic Cardiovascular Disease in HIV Infected Adult African American Females Using ACC/AHA 2013 Pooled Cohort Risk Equation (Findings from a Minority Healthcare University Institute in Washington DC, USA)
Back ground: Data on the patterns of cardiovascular disease (CVD) risk factors in HIV-infected African American Females (AAF) is limited due to their under-representation in epidemiological studies. We examined patterns of CVD risk factors and estimated 10-year primary risk of Atherosclerotic Cardiovascular Disease (ASCVD) in HIV-infected [on highly active antiretroviral therapy (HAART)], and compared with HIV-uninfected adult AAF seeking routine medical care in a minority healthcare institute in Washington DC, USA.
Methods: The study cohort comprised of HIV-infected and age-matched HIV-uninfected adult (age > 20 years) AAF seeking routine health and HIV care (3-6 month intervals) at a large minority healthcare university institute. Data on demographic and HIV characteristics as well as cardiovascular risk profile was compared in participants with a minimum of five clinic visits since registration. Race adjusted, pooled cohort equation was used to estimate and compare 10-year primary risk of ASCVD in HIV-infected females (age ≥ 40 to 79 years), free of pre-existing CVD at baseline to their age-matched controls.
Results: The mean (SD) age, systolic blood pressure, and BMI of 325 (N) patients (67% HIV-infected), was 52 (15) years, 126 (16) mmHg, and 30 (9) kg/m2, respectively. We observed that the HIV-infected (95% on HAART) females were younger [mean (SE) age; 47 (1.6) vs. 62 (1.3) years], had better controlled systolic blood pressure [132 (2.4) vs.139 (1.7) mmHg], lower proportion of diabetics (14% vs. 31%), and had a higher proportion of smokers (52% vs. 31%), compared to HIV-uninfected females (all p= < 0.01). There were no differences in the mean BMI, total and high-density cholesterol between the two female groups (all p = > 0.05). The 10-year primary risk for ASCVD in HIV-infected (age ≥ 40-79 years, 72% on HAART) compared to HIV-uninfected females was statistically different at baseline [mean (SE) risk score; 5.3 (1.5) % vs. 8.5 (1.3) %, p = 0.03)], but not at the last clinic visit [(5.6 (1.1) % vs. 7.5 (0.9) %, p= 0.11)]
Conclusions: From a minority cohort of a large metropolitan area, we report evidence of favorable CVD risk profile in HIV-infected AAF on HAART compared to their age-matched controls. However, the 10-year primary risk for ASCVD was similar over time between the two groups of females.
Author Disclosures: M. Jalloh: None. T. Blair: None. K. Tuffuor: None. J. Tesfay: None. R. Mandlewala: None. D. Roberts: None. C.J. Maxwell: None. M. Amer: None.
- © 2015 by American Heart Association, Inc.