Abstract P225: Longitudinal Association Between Body Weight Change and 6-Year Change of Serum Cholesterol Levels in Japanese Men
Objective: To investigate the longitudinal relationship between body weight (BW) change and years-long change of cholesterol levels in a prospective cohort study.
Participants: A total of 2585 male employees aged 25-53 years without use of lipid-lowering drug in a metal products factory in Japan.
Measurements: Total cholesterol (TC) level was measured by enzymatic assay and HDL cholesterol (HDL-C) level was measured using direct methods. Physical examinations and information on lifestyle and use of medicine were annually measured or confirmed from 2003 (baseline) to 2009. The associations between difference of BW from 2003 to 2008 and 6-years change of cholesterol levels from 2003 to 2009 were analyzed with generalized estimating equation models. Covariates in full adjusted model were age, the other two cholesterol levels among TC, HDL-C, or T/H ratio, body mass index, and smoking and drinking status in baseline.
Results: Mean ± standard deviation (SD) of age, height, and BW in 2003 was 39.3 ± 8.0 years, 170.6 ± 6.0 cm, and 68.2 ± 9.9 kg, respectively. Mean ± SD of BW in 2008 was 68.8 ± 10.2 kg. Mean and SD of TC and HDL-C levels and proportion of TC/HDL-C ratio ≥ 5 (TH5) in 2003 were 199.2 ± 33.8 and 57.5± 13.7 mg/dl and 10.5 %, respectively. These cholesterol levels in 2009 were 206.5 ± 33.5 and 58.1 ± 13.9 mg/dl and 11.4 %, respectively. In full adjusted model, 1 kg increase of BW in 5 years was significantly associated with 1.1 mg/dl higher TC (P < 0.001), 0.4 mg/dl lower HDL-C (P < 0.001), and greater TH5 (odds ratio: 1.11, P < 0.001) in 6 years.
Conclusions: Beyond relevant covariates, increasing BW significantly elevated TC and decreased HDL-C level.
Author Disclosures: S. Nagasawa: None. M. Sakurai: None. K. Koshi Nakamura: None. K. Miura: None. Y. Morikawa: None. M. Ishizaki: None. T. Kido: None. Y. Naruse: None. Y. Suwazono: None. K. Nogawa: None. H. Nakagawa: None.
- © 2015 by American Heart Association, Inc.