Abstract P223: HDL Efflux Capacity, HDL Particle Number, and Carotid Artery Lipid Rich Necrotic Core Plaque: The Chicago Healthy Aging Study
Background: Associations between HDL efflux capacity, HDL particle number and carotid artery wall thickness have been reported. It is unclear if HDL efflux capacity and particle number are associated with the presence of carotid lipid rich necrotic core (LRNC), a marker of high-risk atherosclerosis.
Methods: We performed carotid magnetic resonance imaging (MR) in 402 Chicago Healthy Aging Study participants (ppts). HDL and LDL particle number were measured with NMR spectroscopy. HDL efflux capacity was measured using a validated ex vivo tissue culture assay. We assessed cross-sectional associations between HDL particle number, LDL particle number, HDL efflux capacity and LRNC in separate logistic regression models.
Results: Mean age of ppts included in this analysis was 73 years and 66% were men; 23% had LRNC. Compared to those without LRNC, ppts with LRNC had significantly lower HDL-C (52 vs. 59 mg/dL p=0.001), higher fasting glucose (103 vs. 99 mg/dL p=0.005) higher triglycerides (119 vs. 101 mg/dL p=0.046), higher systolic blood pressure (129 vs. 125 mmHg, p=0.001), and a higher LDL particle number (1107 vs. 1044 nmol/L p=0.02). The highest quartile of LDL particle number was significantly associated with LRNC with adjustment for age, sex, and race. In multivariable adjusted models (see Table), there were no significant associations between efflux capacity, HDL particle number, or LDL particle number and LRNC.
Conclusions: In this study of older adults, we did not observe associations of HDL particle number or efflux capacity with LRNC on carotid MR imaging.
Author Disclosures: J. Wilkins: None. K. Mutharasan: None. A.T.K. Singh: None. C.S. Thaxton: None. M. Daviglus: None. D.M. Lloyd-Jones: None. J.D. Berry: None.
- © 2015 by American Heart Association, Inc.