Abstract P211: Age-Related Trajectories of Lipids and Lipoproteins: The Impact of Cardiorespiratory Fitness
Introduction: Although age-related longitudinal changes of lipids and lipoproteins have been described, there are limited data on these trajectories for the life course in adults. Furthermore, evidence on the effect of cardiorespiratory fitness (CRF) on these trajectories is scarce.
Hypothesis: We assessed the longitudinal, aging trajectory of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and non- high-density lipoprotein cholesterol (non-HDL-C), and then determined whether CRF modifies the age-associated trajectory of TC, LDL-C, TG, HDL-C, and non-HDL-C in healthy men.
Methods: Data came from 11,418 men aged 20-90 years without known high cholesterol, high triglycerides, cardiovascular disease, and cancer at baseline and during the follow-up from the Aerobics Center Longitudinal Study. There were 43,821 observations spanning from 2 to 25 (mean, 3.5) health examinations between 1970 and 2006. CRF was quantified by a maximal treadmill exercise test. Marginal models using generalized estimating equations were applied.
Results: TC, LDL-C, TG, and non-HDL-C presented similar inverted U-shaped quadratic trajectories with aging in which gradual increases were noted until the middle 40s to the early 50s with the subsequent declines (all P<0.0001); whereas HDL-C showed a steady increase with aging (P<0.0001). CRF was consistently shown as a protective factor for abnormal lipid and lipoprotein profiles, and this prominent effect most appears between early 20s and early 60s for TC, LDL-C, and non-HDL-C; early 20s and mid 70s for TG and HDL-C. Compared to men with higher CRF, those with lower CRF developed abnormal values around middle 20s through late 30s: TC (≥200 mg/dl), LDL-C (≥130 mg/dl), non-HDL-C (≥160 mg/dl), and TG/HDL-C ratio (≥3.0). Especially, abnormal values for TC and LDL-C in men with low CRF were observed around 15 years earlier compared to those with high CRF, respectively. After adjusting for time varying covariates such as waist circumference, percent body fat, fasting plasma glucose, systolic and diastolic blood pressure, smoking status, alcohol drinking status, and physical activity habit, a significant interaction was found between age and CRF in each trajectory, indicating that CRF was more strongly associated with the aging trajectories of lipids and lipoproteins in young to middle-aged men than in older men.
Conclusions: Our investigation reveals a differential trajectory of lipids and lipoproteins with aging according to CRF in healthy men, and suggests that promoting increased CRF levels may help delay the development of dyslipidemia.
Author Disclosures: Y. Park: None. X. Sui: None. J. Liu: None. H. Zhou: None. P.F. Kokkinos: None. C.J. Lavie: None. C.J. Lavie: None. S.N. Blair: None.
- © 2015 by American Heart Association, Inc.