Abstract P203: Protective Factors Against Hypertension Progression Among Non-Hypertensive African Americans: The Jackson Heart Study
Background: Hypertension (HTN) is a major cardiovascular disease risk factor. African Americans are particularly at risk for developing HTN and having HTN-related health events. This study aimed to determine the percentage of the initial normotensive African American Jackson Heart Study (JHS) cohort participants who remained normotensive during follow-up and factors associated with remaining normotensive.
Methods: JHS participants without HTN (i.e., blood pressure (BP) <140/90 mm Hg and no current antihypertensive medication use) at baseline exam (2000-2004; n=1,543; median age: 48.1 years) were followed and their BP ascertained at exam 2 (2005-2008; median follow-up: 4.8 years). HTN non-progression rates among participants were described by gender and baseline age and JNC VI normotensive BP category (optimal, ≤119/79 mm Hg; normal, 120-129/80-84 mm Hg; and high normal, 130-139/85-89 mm Hg). Multivariable logistic regression models, stratified by gender, examined possible associations of non-modifiable (e.g., age) and modifiable (e.g., cigarette use) factors with remaining normotensive (P<.05).
Multiple imputation was used to account for missing covariate data.
Results: Overall, 64.7% of the participants remained normotensive at follow-up, including: 62.3% of women; 68.6% of men; 78.9%, 63.7%, and 52.6% of participants aged 18-39, 40-59, and 60-94 years, respectively; and 79.6%, 60.3%, and 40.2% of participants with optimal, normal, or high-normal BP status at baseline, respectively. Factors associated with non-progression were identified (Figure).
Conclusion: About two-thirds of JHS participants who were normotensive at baseline remained normotensive after 5 years of follow-up, a substantially lower rate than reported in other cohort studies with smaller proportions of African American participants. Multiple gender-specific modifiable protective factors were identified that could be useful in the development of interventions to help African Americans remain normotensive.
Author Disclosures: M.D. Ritchey: None. J. Baumgardner: None. F. Loustalot: None. G. Imperatore: None. A. Correa: None.
- © 2015 by American Heart Association, Inc.