Abstract P185: A Differential Prospective Association Between Serum Carotenoids and Tocopherols Occurs with Coronary Artery Calcification
Dietary carotenoids and tocopherols, but not supplements, have been associated with the prevention of cardiovascular disease. To better understand this observation, we examined the association between the carotenoids and tocopherols and the incidence of coronary artery calcification (CAC) a measure of subclinical coronary artery disease. Circulating carotenoids and tocopherols reflect their dietary intakes and post-intake metabolism. We evaluated the sum of carotenoids (4 of the 5 major circulating carotenoids (Sum4Carot): zeaxanthin/lutein, beta-cryptoxanthin, alpha-carotene and beta-carotene, excluding lycopene. Alpha and gamma-tocopherol were evaluated as individual variables. In this study, serum carotenoids and tocopherols were measured by HPLC in CARDIA exam year 15. CAC was measured at exam years 15, 20, and 25 by computed tomography (CT) and expressed as incidence (present or absent among those with no CAC at year 15). Associations were analyzed by Cox Proportional Hazards methods.
Results: See table below. A significant (p for trend<0.007) inverse association was found between the year 15 Sum4Carot and CAC. The association remained significant following adjustment for CVD-related factors (model specified in tabular footnote). Year 15 alpha-tocopherol was not associated with CAC, but gamma-tocopherol had a positive association with CAC (p<0.0001). The association of carotenoids with CAC occurred in middle aged adults (mean age 50, exam year 25). While all of these compounds are antioxidants, high levels of carotenoids were associated with less incident CAC, while high gamma-tocopherol associated with more incident CAC, and alpha-tocopherol had a neutral association. Thus, these compounds may be associated with CVD through non-antioxidative mechanisms. The association of carotenoids and tocopherols measured in early middle-age (mean age 40, year 15) with the development of CAC through middle-age emphasize the importance of diet and lifestyle throughout the lifecourse.
Author Disclosures: M.D. Gross: None. A. Hozawa: None. A. Odegaard: None. J.J. Carr: None. O. Sanchez: None. J.R. Suarez: None. D.R. Jacobs: None.
- © 2015 by American Heart Association, Inc.