Abstract P166: Pregnancy Characteristics and Subclinical Arterial Disease in the Adult Offspring
Introduction: There is mounting evidence that the intrauterine environment affects the risk of cardiometabolic disease in the adult offspring. Birth weight, pre-pregnancy BMI, and smoking during pregnancy are associated with offspring obesity, blood pressure, and changes in lipid and glucose metabolism. We studied subclinical disease mechanisms that may account, at least in part, for this association by examining the associations of birth weight, pre-pregnancy BMI, and smoking during pregnancy with offspring measurements of subclinical arterial disease.
Hypothesis: We assessed the hypothesis that birth weight, pre-pregnancy BMI, and smoking during pregnancy are associated with offspring subclinical arterial characteristics at age 32.
Methods: Using the EndoPAT 2000 device we measured the Augmentation Index (AI), a measurement of arterial stiffness, and the Reactive Hyperemia Index (RHI), a measurement of endothelial function, in 400 subjects from the Jerusalem Perinatal Study Family Follow-up Study (JPS1). The JPS1 includes data on maternal and pregnancy characteristics collected from an interview taken shortly after birth; weight, height, and BP measurements collected at age 17; and a detailed interview, and physical exam conducted at age 32. We repeated our models adjusting for offspring BMI at age 17 and age 32 and for other maternal and offspring lifestyle, socioeconomic, and demographic characteristics.
Results: We found an inverse linear association between birth weight and AI (β=-0.439, 95% CI (-0.830)-(-0.048) for a 100g increase in birth weight) limited to females, that remained after adjustment for offspring obesity but was attenuated after adjustment for maternal and offspring characteristics. We did not find an association between birth weight and RHI. We found a non-linear association between pre-pregnancy BMI and RHI that remained after adjustment for maternal and offspring characteristics, including offspring obesity. The association had an inverse ‘U’ shape. For example, compared to a pre-pregnancy BMI of 19 kg/m2, a pre-pregnancy BMI of 24 kg/m2 was associated with a 0.14 higher mean offspring RHI (95% CI 0.004-0.28), while compared to a pre-pregnancy BMI of 29 kg/m2, a pre-pregnancy BMI of 34 kg/m2 was associated with a 0.18 lower mean offspring RHI (95% CI -0.40-0.002). We did not find an association between pre-pregnancy BMI and offspring AI. There was no evidence of an association between smoking during pregnancy and offspring arterial characteristics.
Conclusion: Our findings contribute to the evidence that maternal pre-pregnancy BMI and offspring birth weight may affect offspring clinical cardiovascular health later in life, and suggest that the effect may be partly due to changes in offspring subclinical arterial characteristics.
Author Disclosures: I. Boger-Megiddo: None. Y. Friedlander: None. B. McKnight: None. S.M. Schartz: None. M. Williams: None. D.S. Siscovick: None.
- © 2015 by American Heart Association, Inc.