Abstract P139: Duration of Childhood Obesity and Relation to Middle-Age Obstructive Sleep Apnea Risk: The Bogalusa Heart Study
Background: Persons with obesity have a high risk of obstructive sleep apnea (OSA); however, the risk duration of childhood obesity confers on later OSA is not clear.
Methods: We prospectively examined the association between duration of overweight and obesity (OW) in childhood and subsequent risk of OSA in 844 middle-aged adults with ≥ 2 measures of body mass index (BMI) between 4 and 18 yrs of age. Childhood OW was defined using age and gender specific BMI ≥85th percentile based on 2000 CDC Growth Charts. Duration of OW was calculated using the presence or absence of OW at each follow-up examination: For participants normal weight at baseline who then became and remained OW through the last examination, or participants who were OW throughout, duration was calculated as the cumulative number of consecutive OW yrs. If participants were OW then ever became normal weight during childhood (N=84), duration was not calculated. After an mean follow-up period of 35 years (in 2010; Interquartile: 1yr), high-risk for OSA, as the primary outcome, was determined using modified Berlin Questionnaire score which excluded obesity as part of its definition. Secondary outcomes included habitual snoring and excessive sleepiness.
Results: Of those included in the analysis, 42.3% were male and 33.6% were Black. At baseline mean (SD) age was 9.9 (2.9) yrs and proportion of OW individuals was 18.2%. At follow-up, individuals were mean age of 42.8 (4.5) yrs and had a mean BMI of 31 kg/m2. In total, 217 (25.7%) had elevated Berlin scores indicating high-risk for OSA. Mean (SD) of OW duration was 5.2 (2.5) yrs. In multivariate log-linear regression models adjusted for baseline age, race, sex, follow-up time, education, current smoking status, regular alcohol consumption, leisure-time physical activity and current OW status, participants with an OW duration of 1-4 yrs, 4-8 yrs, and 8+ yrs were 1.19 (95% CI: 0.90 - 1.57), 1.23 (0.92 - 1.63), and 2.29 (1.67 - 3.15) times more likely to be high-risk for OSA as compared to those who were never OW. Significant linear trends were present across categories of OW duration (P for trend: 0.006). Similar positive trend was observed for habitual snoring but not for excessive sleepiness. There was no significant effect modification by race or sex.
Conclusion: This community-based cohort study suggests that longer duration of OW in childhood was associated with high-risk for OSA in middle-age.
Author Disclosures: T. Hu: None. S. Bertisch: None. W. Chen: None. E. Harville: None. S. Redline: None. L. Bazzano: None.
- © 2015 by American Heart Association, Inc.