Abstract P132: Association of Cardiovascular Risk Factors with Cognitive Function: Results from the Italian Health Examination Survey 2008-2012
Background: The increase in life expectancy has resulted in a growing prevalence of cognitive impairment. Several studies have explored the association with cardiovascular (CV) risk factors (RF), but methodological differences in RF collection and definitions do not allow to draw inferences on the general population. The aims of this study was to describe the association between CVRF (blood pressure, total and HDL cholesterol, smoking habit) and cognitive function in a random sample of community-dwelling older population (65-79 years).
Methods: Data from the Italian Health Examination Survey 2008-2012, a nationwide cross-sectional population-based survey, were used. Blood pressure (BP), pulse pressure (PP) as the difference between systolic (SBP) and diastolic blood pressure (DBP), total (TC), high density lipoprotein cholesterol (HDL) and TC-HDL were assessed; cognitive function was investigated using the Folstein’s Mini-mental state examination (MMSE) test. Cognitive impairment was defined by MMSE score < 1 standard deviation, after controlling for age and educational level. Multiple regression analysis was performed adjusting for age, sex, education, marital status and area of residence; RF were entered as continuous variables.
Results: Out of 8714 adults (35-79 years), 1474 subjects aged 65-79 years (71.5±4.4), 47% women, were studied. Cognitive impairment was found in 13.9% of participants (15.8% in women vs 12.2% in men, p= 0.05). Stratifying participants into RF tertiles, the lower the DBP the lower the crude MMSE score (p for trend= 0.034), whereas no differences were found for SBP and PP; the lower the TC the lower the crude MMSE (p for trend= 0.043), whereas no differences were found for HDL and TC-HDL values. Smokers were not characterized by lower MMSE (26.0±3.4 vs 26.2±3.3). By multiple regression analysis neither DBP (B=0.002; 95%CI= -0.013 - 0.018; p= 0.765) and TC (B= -0.001; 95%CI= -0.005 - 0.003; p= 0.770) resulted associated to MMSE variability. Effect of DBP and TC on MMSE appeared to be entirely attributable to the age effect. MMSE variability was explained only by age, educational level and area of residence.
Conclusions: The direction of the association between CVRF and cognitive function remains vague. Future longitudinal studies describing changes in CVRF throughout life in the general population are deemed necessary to disentangle the predictive contributions of age and cardiovascular risk factors on cognitive function.
Author Disclosures: G. Viscogliosi: None. S. Giampaoli: None. D. Vanuzzo: None. C. Donfrancesco: None. F. Dima: None. S. Vannucchi: None. C. Meduri: None.
- © 2015 by American Heart Association, Inc.