Abstract P124: Ideal Cardiovascular Health During Adult Life and Cardiovascular Structure and Function among the Elderly
Introduction: The AHA has identified seven ideal cardiovascular (CV) health metrics to target primary prevention of CV disease, including heart failure. The relationship between the consistent attainment of these metrics in adulthood and CV structure and function in late-life is not well described.
Hypothesis: We hypothesized that the greater number of ideal CV health metrics consistently achieved in adulthood will be associated with better cardiac and arterial function when elderly.
Methods: The following six ideal CV health metrics were assessed in Atherosclerosis Risk in Communities (ARIC) study participants at 5 exam visits between 1987 and 2013 (visits 1-4 in 1987-98, visit 5 in 2011-13): nonsmoking, body mass index <25 kg/m2, untreated total cholesterol <200 mg/dL, untreated blood pressure <120/<80 mmHg, fasting blood glucose <100 mg/dL. Diet was not assessed due to incomplete serial data. Ideal CV health consistently attained was defined as the minimum number of metrics attained at Visits 1 to 5, and was analyzed in relation to echo measures of cardiac structure and function, arterial stiffness, and soluble cardiac biomarkers assessed at Visit 5 in 5,903 participants free of CV disease at Visit 5.
Results: At Visit 5, median age was 75.2 years (IQR 71.7, 79.7), 42% were male, and 21% black. At least 4 metrics were consistently attained in 6%, with 3, 2, 1, and 0 metrics consistently attained in 14%, 35%, 35%, and 12% respectively. Greater number of metrics consistently attained was associated with better LV structure, systolic and diastolic function, less arterial stiffness, and lower NT-proBNP and high sensitivity troponin T at Visit 5 (Table).
Conclusions: In this community-based cohort, greater number of ideal CV health metrics consistently attained over an approximately 26 year span was associated with better cardiovascular structure and function when elderly.
Author Disclosures: A.M. Shah: B. Research Grant; Modest; Novartis, Gilead. B. Claggett: None. A.R. Folsom: None. P.L. Lutsey: None. S.D. Solomon: None.
- © 2015 by American Heart Association, Inc.