Abstract P101: Associations of Adiposity and Atrial Fibrillation in Older Adults: the Health ABC Study
Introduction: Obesity is a well-recognized, modifiable risk factor for atrial fibrillation (AF). Limited studies have examined adiposity measures other than body mass index (BMI) and AF risk. We examined associations of adiposity measures with incident AF in a biracial cohort of older adults. Given the extensive racial differences between obesity and AF, we assessed for racial differences in relating adiposity and AF.
Methods: The Dynamics of Health, Aging, and Body Composition Study is a prospective cohort of 3,075, community-dwelling, older adults. Adiposity measures were determined using anthropometry [BMI and abdominal circumference (AC)], CT [subcutaneous and visceral fat area (SAT, VAT)] and DXA (total and percent fat mass). AF was identified from the Center for Medicare and Medicaid Services. We determined the associations between adiposity measures and the 10-year risk of incident AF using Cox proportional hazards models. We examined for interactions between race and adiposity measures with the outcome of AF.
Results: The cohort consisted of 2,717 participants (mean age 74±3 years, 51.7% women, 41.4% black). The 10-year incidence of AF was 16.6 (95% CI: 14.9-18.3) per 1000 person-years (371 events). In multivariable-adjusted models, every 1-SD increase in BMI, AC and total fat mass was associated with a 13-16% increase in AF risk (HR: 1.14, 95%CI: 1.02-1.28, HR:1.16, 95%CI: 1.04-1.28 and HR: 1.13, 95%CI: 1.002-1.27). Percent fat mass, SAT and VAT area were not associated with incident AF. We did not identify effect modification by race between the adiposity measures and AF risk. Figure 1 shows the multivariable-adjusted splines relating BMI and risk of AF in whites and blacks.
Conclusion: We determined that BMI, AC and total fat mass, but not SAT or VAT are associated with 10-year AF risk in a biracial cohort of older adults. As obesity is one of the few modifiable AF risk factors, future studies are required to evaluate how weight change can modify the incidence of AF.
Author Disclosures: K.N. Aronis: None. N. Wang: None. C. Phillips: None. E.J. Benjamin: None. G.M. Marcus: None. A.B. Newman: None. N. Rodondi: None. S. Satterfield: None. T.B. Harris: None. J.W. Magnani: None.
- © 2015 by American Heart Association, Inc.