Abstract P064: Association of Cardiorespiratory Fitness and Submaximal Blood Pressure Among Young Healthy Men- A Reverse J-curve Pattern Relationship
Objectives: Exaggerated blood pressure (BP) response during exercise is an important marker of cardiovascular events that are associated with incident hypertension, atherosclerosis, myocardial infarction, coronary artery disease and stroke. Cardiorespiratory fitness (CRF) is associated with a lower risk of all-cause and cardiovascular disease (CVD) mortality. The purpose of this study was to examine the association between CRF and submaximal BP at various stages of Graded Exercise Test (GXT) in young healthy men.
Methods: GXT using a Modified Bruce protocol on a treadmill was performed on 191 normotensive (resting BP < 140/90 mm Hg) men aged 20-35years. BP was recorded at each stage of the protocol. Quintiles of fitness were established on the basis of peak Vo2 with the 1st quintile being the lowest fit group and 5th quintile being the highest fit group.
Results: The mean peak Vo2 in quintiles 1, 2, 3, 4 and 5 were 32.3, 39.1, 43.4, 48.1 and 55.5 respectively. A reverse J-curve pattern relationship was evident between CRF and submaximal systolic BP. Men in the 3rd quintile displayed the lowest submaximal systolic BP levels across all the stages of GXT. There was a substantial decrease in submaximal BP from quintile 1 to 3 followed by an increase in higher quintiles, although still lower than quintile 1. The J-shaped relationship remained significant after controlling for potential confounders, including age, race, body fat percentage, resting systolic BP, smoking and alcohol intake (Quadratic trend P value< 0.05).
Conclusion: These findings suggest that in young healthy men, there is a reverse J-curve pattern relationship between submaximal BP and CRF. Improving the CRF from low to average to high will progressively decrease submaximal systolic BP and CVD risks. However, the benefits from improvements in the CRF and prevention of increased submaximal systolic BP plateau at a point, beyond which there are no additional benefits or loss of the benefits (in a reverse J-curve pattern).
Author Disclosures: V.K. Prasad: None. C. Drenowatz: None. G.A. Hand: None. C.C. Lavie: None. X. Sui: None. M. Demello: None. S.N. Blair: None.
- © 2015 by American Heart Association, Inc.