Abstract P037: Effect of a Family Based Intervention on Biomarkers of Diet Quality/Endogenous Metabolism and BMI z-score
Developing strategies to prevent excess weight gain during childhood is critical to support efforts to stem the current juvenile obesity epidemic and associated long-term adverse cardiometabolic consequences. The objective was to assess how participation in a family-based weight management intervention affected biomarkers of diet quality/endogenous metabolism and cardiometabolic outcomes in children aged 7-12 years (n=309) with baseline BMI z-score (BMIz) >85th percentile. Families were randomized to a control group, receiving a booklet targeting healthy eating behaviors/increasing physical activity, and quarterly visits to review lifestyle recommendations or an experimental group, receiving weekly sessions for 3 months including targeted diet strategies (increasing highly pigmented fruit/vegetable and fish intake; substituting non-fat/low-fat for full-fat dairy products; and reducing meat, fried food and savory snack intakes) and physical activity curriculum followed by 9 monthly sessions. Biomarkers of nutrient intake and metabolism (RBC fatty acid profiles, plasma carotenoids, vitamins A, E, K and dihydrovitamin K) were measured using GC or HPLC. Presented are results of pooled group analysis between change in age and sex standardized BMIz and dietary/endogenous metabolism biomarkers. Using multivariate logistic regression (odds ratios [95% confidence intervals]), MUFA 16:1n-7 (0.26 [0.07-0.98]), an indicator of de novo lipogenesis, was negatively associated with, while 18:1n-9trans (13.5 [1.5-128.1]), a biomarker of partially-hydrogenated fat, and lycopene (1.02 [1.01-1.05]), a biomarker for tomato-based foods, were positively associated with change in BMIz. Delta-6-desaturase (D6D; 20:3n-6/18:2n-6) and delta-5-desaturase (D5D; 20:4n-6/20:3n-6) activities, indicators of endogenous fatty acid metabolism, were negatively (0.32 [0.15-0.68]) and positively (1.10 [1.01-1.22]) associated with change in BMIz, respectively. Results suggest that foods high in partially-hydrogenated fat and tomato-based products (e.g., pizza) have an adverse effect on change in BMIz. Additionally, the changes in D6D and D5D indices suggest that in vivo metabolism is predictive of change in BMIz in this cohort of high-risk children.
Author Disclosures: N.R. Matthan: None. X. Xue: None. Q. Gao: None. J. Wylie-Rosett: None. A.H. Lichtenstein: None.
- © 2015 by American Heart Association, Inc.