Abstract P033: Sugar Sweetened Beverage Intake, Chromosome 9p21 Variants, and Risk of Myocardial Infarction in Hispanics
Introduction: Chromosome 9p21 variants are among the most robust genetic markers for coronary heart disease (CHD). Our previous study showing that intake of sugar-sweetened beverages (SSB) interacts with genetic factors to affect risk of obesity, a major CHD risk factor, suggests that SSB could modify the effect of chromosome 9p21 variants on CHD. SSB are the main source of added sugar in the diet among Hispanics living in the United States and Latin America. Thus, this study is aimed to test whether SSB intake modifies the association between chromosome 9p21 variants and CHD risk in Hispanics.
Methods: The study population included 1,603 incident cases of non-fatal myocardial infarction (MI) and 1,778 population-based controls living in Costa Rica. Three independent single-nucleotide polymorphisms (SNPs) at chromosome 9p21 locus were genotyped. SSB intake was defined as the frequency of daily servings of commercially available and home-made sweetened beverages, and fruit juice assessed using a food-frequency questionnaire. Odds ratios were estimated using unconditional logistic regression models.
Results: A significant interaction (p=0.003) was found between SSB intake and the rs4977574 variant. The per-risk-allele odds ratio for MI was 1.45 among the participants in the highest tertile of SSB intake and 0.96 among the participants in the lowest tertile (Figure Panel A). Results for variants rs2383206 and rs1333049 did not reach statistical significance (P for interaction =0.07 and 0.15, respectively). A genetic risk score derived from the sum of risk alleles of the 3 SNPs, also showed a significant interaction with SSB intake on MI risk (P for interaction=0.03, Figure Panel B), although the magnitude of this effect was attenuated.
Conclusions: Our data suggest that unhealthy dietary habits such as higher intake of SSB could exacerbate the effects of the 9p21 variants on CHD.
Author Disclosures: Y. Zheng: None. Y. Li: None. T. Huang: None. H. Cheng: None. H. Campos: None. L. Qi: None.
- © 2015 by American Heart Association, Inc.