Abstract P026: Gender Difference of the Association of Serum Polyunsaturated Fatty Acids With the Evolution of Hemodynamics
Background: While abnormal hemodynamics and abnormal lipid profiles of polyunsaturated fatty acids (PUFAs) are noted as risk for cardiovascular disease, their association has not been fully clarified.
Objective: We examined whether plasma PUFAs (Arachidonic acid (AA), Eicosapentaenoic acid (EPA), and Docosahexaenoic acid (DHA)) levels are associated with change of hemodynamics in healthy middle aged Japanese subjects.
Design: 1,527 healthy Japanese subjects (316 women) were prospectively followed up for three years from 2008. Central blood pressure (CBP), brachial pulse wave velocity (baPWV), and radical augmentation index (rAI) were measured as marker of hemodynamics. CBP and rAI were measured by arterial applanation tonometry, and baPWV was measured using volume plethysmographic apparatus. Multivariate linear regression adjusted for established risk factors for raised blood pressure were performed to evaluate the association between each PUFAs and change of hemodynamics (CSBP, ba PWV, raAI) during 3years. We conducted overall and stratified analyses by gender.
Results: Mean age of women and that for men was 40 ± 6 and 41 ± 6 years, respectively. In a multivariable model controlling for established risk factors for raised BP, all of PUFAs were not significantly associated with any change of hemodynamics overall. However, only among women, plasma DHA but not EPA and AA was significantly associated with change in CBP. 1standard deviation (SD) increase of plasma DHA was associated with decreased CBP of 1.77 mmHg (P<0.05).
Conclusions: The association of serum PUFAs with the evolution of central hemodynamics may be different between genders. Especially, low DHA levels may be a risk for the progression of abnormal central hemodynamics in middle aged healthy women.
Author Disclosures: C. Matsumoto: None. H. Tomiyaa: None. A. Yamashina: None.
- © 2015 by American Heart Association, Inc.