Abstract P020: Multivitamin Use and Risk of Hypertension in Prospective Cohort Study of Women
Introduction: Despite the widespread use of multivitamin supplements, little is known regarding its effects on blood pressure (BP) and the development of hypertension. We therefore sought to prospectively investigate how multivitamin use was associated with incident hypertension among middle-aged and older women.
Hypothesis: Multivitamin use is associated with the risk of hypertension among middle-aged and older women.
Methods: We studied 29,082 women from the Women’s Health Study aged ≥45 years and free of cardiovascular disease, cancer and hypertension at baseline. At baseline, women self-reported lifestyle, clinical and dietary factors, including multivitamin and supplement use. Cases of incident hypertension were identified during an average of 11.5 years follow-up through self-reports from annual follow-up questionnaires. Incident hypertension was defined as either a new diagnosis of hypertension by a physician, initiation of antihypertensive medication, systolic BP ≥140 mmHg, or diastolic BP ≥90 mmHg.
Results: During a mean follow-up of 11.5 years, we identified 16,810 cases of incident hypertension. We found that current multivitamin use was not associated with the risk of hypertension in age and multivariable-adjusted models (Table 1). When we investigated the duration of multivitamin use reported at baseline, we observed no association with the risk of hypertension. The lack of effect was consistent across categories of age, smoking, and fruit and vegetable intake.
Conclusions: The results from this prospective study of middle-aged and older women suggest that multivitamin use is not associated with the risk of developing hypertension. Additional observational studies and randomized trials are needed to clarify whether multivitamin use would affect BP levels and have a role in the prevention of hypertension.
Author Disclosures: S. Rautiainen: None. L. Wang: None. I. Lee: None. J. Gaziano: None. J.E. Buring: None. H.D. Sesso: None.
- © 2015 by American Heart Association, Inc.