Abstract MP82: Associations of Positive Psychological Well-being on Changes in Allostatic Load: Multi-Ethnic Study of Atherosclerosis (MESA)
Background: Cumulative multi-system physiological dysregulation may represent an important pathway linking psychological well-being to cardiovascular disease (CVD) risk but this relationship is poorly understood. This study examines the cross-sectional associations of psychological well-being (positive affect and dispositional optimism) with allostatic load (AL), i.e., cumulative multi-system physiologic burden.
Methods: We used data collected from approximately 4,000 adults aged 45-84 who participated in the Multi-Ethnic Study of Atherosclerosis (MESA) with initial baseline enrollment in 2000-2002. Positive affect was calculated by summing four positively-worded items included in the Center for Epidemiologic Studies Depression Scale Revised. The Life Orientation Test-Revised was used to assess levels of dispositional optimism. A composite score for AL was derived from the following physiological components: wait-to-hip ratio, triglycerides, LDL and HDL cholesterol, glucose, systolic blood pressure, resting heart rate, and pulse pressure. Multiple linear regression was used to examine cross-sectional associations of positive affect and AL at baseline (2000-2002) and optimism and AL at the first follow-up visit (2002-2004).
Results: In models adjusted for socio-demographic factors, psychological well-being was not significantly related to AL for the total sample. However, effect modification was evident by sex and race/ethnicity when examining the association of optimism and AL. Optimism was inversely associated with AL for Caucasian men, after adjustment for socio-demographic factors (Table 1), with a 1-unit increase in optimism associated with a 0.07 reduction in AL (p = 0.03).
Conclusion: The current study offers preliminary evidence for an inverse association between dispositional optimism and AL among Caucasian men. Prospective analyses to come.
Author Disclosures: R. Hernandez: None. K. Kershaw: None. T. Seeman: None. J. Boehm: None. T. Vu: None. H. Ning: None. D. Lloyd-Jones: None.
- © 2015 by American Heart Association, Inc.