Abstract MP58: Vitamin D Consumption is Not Associated with Incident Heart Failure: the Physicians' Health Study
Background: Previous research investigating the relationship between vitamin D supplementation and incident heart failure (HF) has yielded equivocal results. Limited research exists on the association of dietary vitamin D consumption and the risk of incident heart failure.
Objective: We sought to test the hypothesis that vitamin D consumption is associated with a lower incidence of heart failure.
Methods and Results: Using a validated food frequency questionnaire, we estimated dietary vitamin D consumption for 19,635 participants of the Physician’s Health Study who were free of HF at baseline. The mean age at baseline was 66.4 ± 9.2 years. Over a mean followup of 9.3 years, 858 cases of incident HF were captured using an annual follow-up questionnaire with validation in a subsample. From the multivariable Cox regression model, hazard ratios (95% CI) of incident HF were 1.0 (reference), 1.49 (1.17 to 1.89), 1.37 (1.07 to 1.75), 1.34 (1.02 to 1.75), and 1.28 (0.94 to 1.75) from lowest to highest quintile of calorie-adjusted vitamin D, respectively, after adjusting for age, BMI, smoking, alcohol, exercise, multivitamin use, fruits and vegetables, chocolate, and breakfast cereal consumption, atrial fibrillation, and valvular heart disease (p for linear trend = 0.71).
Conclusions: In this prospective study of male health professionals, dietary vitamin D consumption is associated with a higher risk of HF.
Author Disclosures: J. Robbins: None. A. Petrone: None. J. Gaziano: None. L. Djousse: None.
- © 2015 by American Heart Association, Inc.