Abstract MP40: Global Burden of Chronic Kidney Disease in 2010: A Pooling Analysis of Population-Based Data Worldwide
Introduction: Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Accurate estimates of the prevalence and global burden of CKD are essential for assigning sufficient priority and resources to its prevention and treatment. We aimed to estimate the global prevalence and absolute burden of CKD in 2010 by pooling data from population-based studies in different world regions.
Methods: We searched published literature from January 1, 1990, to June 30, 2014 using MEDLINE, supplemented by manually searching bibliographies of retrieved articles. We included studies that reported sex- and age-specific prevalence of CKD in representative population samples. CKD stages 1-5 was defined as the presence of albuminuria/proteinuria or an estimated-glomerular filtration rate <60 ml/min/1.73m2. All data were extracted independently and in duplicate by at least two investigators using a standardized protocol and data-collection form. Sex- and age-specific prevalence estimates were applied to the 2010 population to estimate the number of people with CKD in each country, world region, and globally.
Results: The age-standardized global prevalence of CKD stages 1-5 among adults aged ≥20 years in 2010 was 10.3% in men (95% confidence interval 10.1 to 10.5%) and 12.1% in women (11.8 to 12.4%): 8.6% in men (8.4 to 8.9%) and 9.6% in women (9.4 to 9.8%) in high-income countries, and 10.6% in men (10.3 to 10.9%) and 12.9% in women (12.5 to 13.3%) in low- and middle-income countries. The estimated total number of adults with any stage of CKD in 2010 was 224.0 million (218.7 to 229.3 million) in men and 278.3 million (272.1 to 284.6 million) in women: 48.3 million (47.1 to 49.5 million) in men and 61.8 million (60.6 to 63.1 million) in women in high-income countries, and 175.7 million (170.6 to 180.9 million) in men and 216.5 million (210.4 to 222.6 million) in women in low- and middle-income countries.
Conclusions: CKD is an important global-health challenge, especially in low- and middle-income countries. National and international efforts on the prevention, detection, and treatment of CKD are needed to reduce its morbidities and mortalities worldwide.
Author Disclosures: K.T. Mills: None. Y. Xu: None. W. Zhang: None. J.D. Bundy: None. C. Chen: None. T.N. Kelly: None. J. Chen: None. J. He: None.
- © 2015 by American Heart Association, Inc.