Abstract MP01: Physical Activity and Incident Cardiovascular Disease in Women: Is the Relation Influenced by Level of Global Cardiovascular Risk?
Background: The inverse association between physical activity and CVD is well-established and has been shown in persons with and without single CVD risk factors. Nonetheless, it is unknown if physical activity is equally beneficial for prevention of CVD among women with varying levels of global cardiovascular risk. Thus, the purpose of this analysis was to determine whether level of cardiovascular risk, as assessed by the Reynolds Risk Score, modifies the association between physical activity and CVD.
Methods and Results: We conducted a prospective analysis among 27,636 women initially healthy women in the Women’s Health Study, followed from 1992 to 2012. Leisure-time physical activity was reported at study entry and updated during follow-up. Participants were divided into 10-year risk groups of < 5%, 5% to < 10%, 10% to < 20%, and ≥ 20% based on the Reynolds Risk Score. The primary outcome was total CVD which included MI, stroke, CVD death, CABG, and PTCA. During a median of 19.1 years of follow-up, we documented 1874 new cases of CVD. After adjustment for other risk factors, the HR of CVD for active (≥ 500 kcal/wk of physical activity, sufficient to meet guidelines) compared to inactive individuals (< 500 kcal/wk) was 0.73 (95% CI: 0.67, 0.80). There was no evidence of effect modification of this association by level of cardiovascular risk (p, interaction = 0.72); physical activity was inversely associated with CVD risk within all 10-year risk groups. When the joint association of physical activity and 10-year cardiovascular risk was examined, women with higher 10-year risk based on the Reynolds score had higher HRs for CVD. However, even among women with ≥ 20% 10-year risk, being physically active was associated with lower risk of CVD (Figure).
Conclusions: In this large prospective cohort of women, global level of cardiovascular risk did not modify the inverse association between physical activity and CVD risk. Thus, women with low as well as high cardiovascular risk can benefit from regular exercise.
Author Disclosures: A.K. Chomistek: None. N.R. Cook: None. E.B. Rimm: None. P.M. Ridker: B. Research Grant; Significant; Research grant support from AstraZeneca and Pfizer. F. Ownership Interest; Significant; Coinventor on patents held by BWH that relate to use of inflammatory biomarkers in CVD and DM that have been licensed to AstraZeneca and Seimens. J.E. Buring: None. I. Lee: None.
- © 2015 by American Heart Association, Inc.