Abstract 52: Purpose in Life and its Relationship to All-Cause Mortality and Cardiovascular Events: A Meta-Analysis
Background: Purpose in life is a component of psychological well-being and has been associated in some studies with reduced mortality. To assess the net impact of purpose in life on cardiovascular events, we performed a meta-analysis of all relevant studies.
Methods: A systemic search was undertaken to identify all studies investigating the relationship between purpose in life, all-cause mortality and cardiovascular events. Unadjusted and adjusted effect estimates were pooled using random effects model.
Results: 10 prospective studies (n =137,142, mean follow-up 8.5 years) were included in the analysis. A significant association was observed between having a higher purpose in life and reduced all-cause mortality [adjusted pooled relative risk (RR): 0.77 (CI: 0.69-0.86), p<0.001] and cardiovascular events [adjusted RR: 0.81 (CI: 0.73-0.90), p<0.001]. Subgroup analyses yielded similar results.
Conclusions: Possessing a high sense of purpose in life is associated with a reduced risk for all-cause mortality and cardiovascular events. Future research should focus on strategies to assist individuals identified as having a low sense of purpose in life.
Author Disclosures: R. Cohen: None. C. Bavishi: None. A. Rozanski: None.
- © 2015 by American Heart Association, Inc.