Abstract 50: Hypertension, Antihypertensive Treatment, Sodium Intake and Cognitive Decline
Objective: Our objective was to investigate the relationships of hypertension, antihypertensive treatment and sodium intake on cognitive decline in older postmenopausal women.
Methods: Prospective follow-up of 6,426 cognitively intact women aged 65 to 79 years old enrolled in the Women’s Health Initiative Memory Study (WHIMS) with a median follow-up of 9.1 years. Dietary sodium intake was determined by food frequency questionnaires. Cognitive functioning was assessed annually by 3MS scores, neurocognitive and neuropsychiatric evaluations. Cognitive decline was identified by the incidence of mild cognitive impairment (MCI) or probable dementia (PD). Cox proportional hazards analyses were used to calculate hazard ratios (HRs) for the risk of cognitive decline.
Results: Hypertension was associated with an increased risk for cognitive decline (HR 1.23; 95% CI 1.06, 1.43; p=0.006) in elderly women. Antihypertensive treatment was related to an increased risk for cognitive decline with women having blood pressure elevations ≥140/90mmHg being at highest risk (HR 1.38; 95% CI 1.12, 1.60; p=0.01) compared to normotensive women without antihypertensive medication. High sodium intake (>1500mg/d) did not significantly alter the risk for cognitive decline in hypertensive women or women with antihypertensive treatment (p for interaction = 0.98 or 0.93).
Conclusions: In elderly postmenopausal women, hypertension or antihypertensive therapy was associated with an increased risk for developing cognitive decline. High sodium intake did not modify the risk for cognitive decline in hypertensive women or women receiving antihypertensive medication.
Author Disclosures: B. Haring: None. C. Wu: None. L.H. Coker: None. A. Seth: None. L. Snetselaar: None. J.E. Manson: None. J. Rossouw: None. S. Wassertheil-Smoller: None.
- © 2015 by American Heart Association, Inc.