In the article by Gale et al, “Mental Disorders Across the Adult Life Course and Future Coronary Heart Disease: Evidence for General Susceptibility,” which was published in the January 14, 2014 issue of the journal (Circulation. 2014;129:186–193. DOI: 10.1161/CIRCULATIONAHA.113.002065), there were errors in reporting some of the results. Specifically, due to coding mistakes during programming, there were errors in the number of men reported as having been diagnosed with some forms of mental disorder at the conscription examination in early adulthood.
Of the 8 diagnostic categories examined, numbers of cases at conscription were reported incorrectly for 5 categories. For 4 of these 5 categories, the correct number of cases is lower than originally reported. The correct number of cases for these 5 categories is as follows: other nonaffective psychoses (n=21), depressive disorders (n=2 138), neurotic/adjustment disorders (n=40 053), alcohol-related disorders (n=3 296), and drug-related disorders (n=4 128). As a consequence, the total number of men diagnosed with a mental disorder at conscription was reported incorrectly. The correct number is 55 933 (5.1% of our sample).
Some of the hazard ratios in the various models for risk of incident coronary heart disease shown in Table 1 (for the whole sample), Table 2 (for men conscripted in 1969–1970 only) and in the online-only Data Supplement Tables II-V and VIII have changed slightly as a result of the changes in case numbers. Given the large number of hazard ratios listed in these tables, the correct versions are not listed here but can be seen in the revised version of the paper and the online supplement. Minor amendments to the text of the results and the first paragraph of the discussion have also been made.
In the original paper, the authors had analyzed diagnoses of other nonaffective psychoses, schizophrenia, and bipolar disorder at conscription together. After the number of cases of other nonaffective psychoses was corrected, only 125 men remained in this group and only 5 of them developed coronary heart disease, too few for reliable estimation of an effect size. The authors have, therefore, omitted all separate analyses of this diagnostic group from Table 1, and the online-only Data Supplement Tables II-V. This is explained in the revised results section.
In the abstract of the paper, the confidence intervals for the age-adjusted hazard ratios (95% CI) for coronary heart disease according to diagnoses of mental disorder at conscription have changed slightly. After correction, age-adjusted hazard ratios ranged from 1.30 (1.05, 1.62) to 1.90 (1.58, 2.38).
The original finding that mental disorder in early adulthood is associated with increased risk of coronary heart disease remains unchanged. The authors regret these errors and any inconvenience they may have caused to the readers of the journal.
- © 2015 American Heart Association, Inc.