In the article by Rashid et al, “Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms”, which appeared in the July 29, 2014 issue of the journal (Circulation. 2014;130:9 431–441. DOI: 10.1161/CIRCULATIONAHA.113.006720), the authors stated that only few investigators have characterized the functional importance of PCSK9 in the small intestine and its regulatory role on the metabolism of triglyceride-rich lipoproteins. A paper from Le May et al1 published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology in 2009 showed that PCSK9-deficient mice display reduced postprandial hypertriglyceridemia and apoB levels following olive oil gavage, and that adenoviral PCSK9 overexpression or targeted ShRNA silencing of PCSK9, respectively, led to increase and reduction of apoB secretion. The authors consider the paper by Le May et al1 central to their story, and its omission from the Discussion and reference list was unintentional.
The authors apologize for the oversight.
- © 2015 American Heart Association, Inc.