Abstract 9904: Endothelial Function is Impaired in Subjects With Decreased Frequency of Tooth Brushing
Introduction: Clinical studies have shown a link between oral health, especially periodontitis, and cardiovascular disease. Poor oral health behavior is associated with increasing risk of cardiovascular disease. Several investigators, including us, have shown that periodontitis is associated with endothelial dysfunction and that treatment of periodontitis improves endothelial function in patients with atherosclerosis as well as in healthy subjects. However, there is no information on the association between oral health behavior and endothelial function. The purpose of this study was to determine the relationships between oral health behavior and endothelial function.
Methods and Results: We had a questionnaire about oral health behavior, frequency of tooth brushing, and measured vascular function, flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation in 190 subjects who underwent health examinations (mean age, 57±18 years), including patients with cardiovascular diseases. We divided the subjects into two groups according to frequency of tooth brushing (twice a day or more and less than once a day). FMD were significantly lower in the less than once a day of tooth brushing group as compared to the twice a day or more of tooth brushing group (3.3±2.2% vs. 5.0±3.0%, P<0.001). There was no significant difference in nitroglycerine-induced vasodilation between the two groups (11.6±5.7% vs. 11.6±5.5%, P=0.99). Multiple stepwise regression analysis for the low tertile of FMD revealed that age, diabetes mellitus and less than once a day of tooth brushing independently remained associated with the low tertile of FMD (Table).
Conclusion: These findings suggest that poor oral health behavior, decreased frequency of tooth brushing, is associated with endothelial dysfunction. Tooth brushing is a simple approach for improving a poor oral condition, and it is expected that appropriate oral health care will improve endothelial function.
Author Disclosures: M. Kajikawa: None. Y. Higashi: None. T. Maruhashi: None. Y. Iwamoto: None. A. Iwamoto: None. N. Oda: None. T. Matsumoto: None. T. Hidaka: None. A. Nakashima: None. K. Noma: None. A. Taguchi: None. Y. Kihara: None.
- © 2014 by American Heart Association, Inc.