Abstract 9688: Association Between Insulin-Like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients With Aortic Stenosis
Introduction: Recent studies have reported a relationship between lower plasma IGFBP-2 levels and altered metabolism linked to visceral obesity. Metabolic abnormalities associated with obesity have been associated with worsening of LV remodeling and dysfunction in patients with AS. Whether IGFBP-2 is involved in these relationships is currently unknown.
Objective: The objective of this study was to examine the relationship between circulating IGFBP-2 and left ventricle (LV) pump function as measured by stroke volume index (SVi) in aortic stenosis (AS) patients with preserved LV ejection fraction (LVEF).
Methods: 208 patients with AS were prospectively recruited in the PROGRESSA study and underwent Doppler-echocardiography. SV was calculated by Doppler in the LV outflow tract and was indexed to body surface area (SVi). Plasma circulating IGFBP-2 levels were measured by ELISA.
Results: Patients with lower IGFBP-2 levels were younger (p <0.0001), had a higher body mass index (p =0.0003) and waist circumference (p =0.01), as well as higher HOMA index (p =0.0005) and lower HDL (p =0.01). Moreover, SVi was decreased in patients with low IGFBP-2 blood plasma levels (p =0.009). After multivariate adjustment for age, gender, LV mass index, aortic valve area and LVEF, lower plasma IGFBP-2 was independently related with lower SVi (p <0.001). After further adjustment for other traditional cardiometabolic risk factors, plasma IGFBP-2 remained associated with SVi (all p <0.05).
Conclusions: In this study, we documented that lower plasma levels of IGFBP-2 are independently associated with lower SVi, a powerful predictor of worse outcomes in the AS population.
Author Disclosures: S. Carter: None. R. Capoulade: None. M. Arsenault: None. É. Bédard: None. J.G. Dumesnil: None. P. Mathieu: None. P. Pibarot: None. F. Picard: None.
- © 2014 by American Heart Association, Inc.