Abstract 9476: Incidence Rates and Risk Factors for Sudden Unexpected Non-Cardiac Death in the Young - A Nationwide Cohort Study in Denmark
Introduction: Upon autopsy of a sudden unexpected death, cause of death can be divided into; 1) those that are sudden cardiac deaths and 2) those that are sudden non-cardiac deaths (SNCDs). Importantly, families of SNCD victims should not be followed in clinics for inherited cardiac diseases. We aimed to report incidence rates, risk factors, and causes of SNCD in a nationwide setting.
Methods: All deaths in persons aged 1-35 years and 36-49 years were included in 2000-2009 and 2007-2009, respectively. Two physicians independently identified all sudden unexpected deaths through review of death certificates. Autopsy reports were collected. A multivariable logistic regression model was used to identify clinical characteristics and risk factors associated with SNCD.
Results: We identified 1,691 sudden unexpected deaths. In 1,039 cases an autopsy was conducted and 286 (28%) deaths were classified as SNCD. The median age in the SNCD population was 32 years; 45% were women. Figure 1 presents incidence rates of SNCD and the proportion of autopsied sudden unexpected deaths being SNCD. Independent risk factors for SNCD were female gender (OR 1.6, 95% CI: 1.1-2.1) and age group 1-35 years vs. 36-49 years (OR 1.6, 95% CI: 1.2-2.2). Patients without cardiac comorbidities were at significantly increased risk of SNCD (5.1 95% CI: 2.8-9.5). The most common cause of SNCD was pulmonary diseases (n=115, 40%) followed by infections disease (n=57, 20%).
Conclusions: Sudden unexpected deaths were caused by non-cardiac diseases in 28% of the cases. Risk factors for SNCD are female gender, young age and no cardiac comorbidity. Further investigation of risk factors for SNCD may help generate future strategies in follow-up of relatives to a non-autopsied sudden unexpected death victim.
Author Disclosures: B. Risgaard: None. T.H. Lynge: None. M. Wissenberg: None. R. Jabbari: None. C. Glinge: None. G.H. Gislason: None. S. Haunsø: None. B.G. Winkel: None. J. Tfelt-Hansen: None.
- © 2014 by American Heart Association, Inc.