Abstract 9448: The Association Between Adiponectin and Type 2 Diabetes and Hypertension in African American Men and Women: The Jackson Heart Study
Introduction: The objective of this study was to assess the effect of adiponectin and its interaction with socioeconomic status (SES) on likelihood of type 2 diabetes and hypertension in 3,663 African American men and women in the Jackson Heart Study.
Hypothesis: It was hypothesized that, after adjusting for confounders, men and women with lower levels of adiponectin would have significantly higher risk of type 2 diabetes and hypertension.
Methods: Separate logistic regression models for type 2 diabetes and hypertension were stratified by sex. Models were analyzed with adiponectin as the primary predictor divided into 4 quartiles with quartile 4 as the highest level and the reference. Sequential multivariate models included age, biological indices (low-density lipoprotein, high-density lipoprotein, total cholesterol, homoeostasis model assessment [[Unable to Display Character: –]] insulin resistance, C-reactive protein), behavioral indices (body mass index, smoking status, physical activity, alcohol consumption status), a fully adjusted model including SES based on annual household income collapsed into 3 categories <$19,999, $20,000 - $49,999, ≤50,000 with ≤$50,000 as the reference, and a fully adjusted model with an interaction term between level of adiponectin and level of SES. A two-tailed level of significance was established as p <.05.
Results: There was no association between adiponectin and type 2 diabetes and hypertension among men. There was an interaction among men who had the lowest level of adiponectin and SES and the likelihood of type 2 diabetes (odds ratio [OR], 95% confidence interval [CI] = 4.77, [0.79, 6.68], p = .02). Adiponectin level was inversely associated with type 2 diabetes among women (OR, 95% CI = 1.47, [1.02, 2.11], p = .04). Women with the lowest level of adiponectin were less likely to be hypertensive (OR, 95% CI = 0.66 [0.46, 0.95], p = .02). There was an interaction among women with the lowest levels of adiponectin and SES being less likely to be hypertensive (OR, 95% = 0.43, [0.25, 0.76], 0.48, [0.36, 0.93], p = .03 and .03, respectively).
Conclusion: Findings reveal significant differential associations between adiponectin and type 2 diabetes and hypertension, including an interaction with SES among AA men and women.
Author Disclosures: S.K. Davis: None. S. Gebreab: None. R. Xu: None. P. Riestra: None. R. Khan: None. A. Sumner: None. D. Hickson: None. A. Bidulescu: None.
- © 2014 by American Heart Association, Inc.