Abstract 9397: Prognostic Implications of Small Aortic Root in Aortic Valve Stenosis
Background: In aortic stenosis (AS), having a small aortic root influences assessment of AS severity as well as treatment strategy. The aim was to test the prognostic implications of having a small aortic root in patients with AS.
Methods: Data from 1563 patients with initially asymptomatic mild-moderate AS enrolled in the Simvastatin and Ezetimibe in Aortic Stenosis study was used. Small aortic root was defined as an aortic diameter <2.60 cm at the sinotubular junction.
Results: A small aortic root was found in 32.6% of patients and twice as frequent among women. In multivariate logistic regression, having small aortic root was associated with lower body height, smaller left ventricular dimensions and wall thickness, higher arterial stiffness and female sex (all p<0.05). In multivariate Cox regression analyses, having a small aortic root at baseline predicted increased cardiovascular morbidity and mortality independent of age, sex, AS severity by energy loss index, hypertension and study treatment (all p<0.05, Table 1).
Conclusion: In AS patients without known cardiovascular disease, having a small aortic root is an independent predictor of higher cardiovascular morbidity and mortality.
Table 1. Small aortic root as predictor of different cardiovascular events in multivariate analyses.
Author Disclosures: E. Bahlmann: None. D. Cramariuc: None. J. Minners: None. M. Lønnebakken: None. S. Ray: None. C. Gohlke-Baerwolf: None. C.A. Nienaber: None. N. Jander: None. J.B. Chambers: None. K. Kuck: None. E. Gerdts: None.
- © 2014 by American Heart Association, Inc.