Abstract 76: Does of Multiple Epinephrine Administration on OHCA Patients Associate with Good Cerebral Performance?
Background: Epinephrine, strong vasoconstrictor, is recommended that administered to OHCA patients every 3 to 5 minutes by the JRC 2010guideline. However, there are no scientific evidence of effectiveness multiple epinephrine administration on OHCA patients.
Purpose: The aim of this study is to determine the effectiveness of the number of epinephrine administration associated with good cerebral performance (CPC) outcome on OHCA patients.
Methods: A total of 925288 OHCA patients registered by the Japan Utstein registry between January 1, 2005 and December 31, 2012. Adult patients whose age from 15 to 89 years with presumed cardiac origin were included in this study. Non-cardiac origin and patients who regained return of spontaneous circulation before EMS arrival were excluded. Total 4679 OHCA patients received single or multiple administration of epinephrine.
Results: One thousand eight hundred forty three OHCA patients received single administration of epinephrine (as single epi group), 1367 OHCA patients did twice(as twice epi group), 739 patients did three times(as three times epi group), and 384 patients did four times(as four times epi-group), 346 patients did 5times and more (as 5times and more epi-group). All patient shows identical back ground (age, gender, bystander CPR ratio and response time), however, CPC-1.2 at one month after for patients with single epi-group was 5.9%, twice epi-group was 2.9%, three times epi-groups was 2.0%, and four times epi wad 2.1% , and 5 times and more epi-groups was 1.4% respectively. There were statistically significant between the groups single epi and other groups (P<.05).
Conclusions: One month of CPC-1/2 ratio fell down progressively with increasing times of administration in epinephrine. However, data suggest that multiple administration of epinephrine were might gave worsen condition than that of first administration.
Author Disclosures: R. Sagisaka: None. H. Takyu: None. H. Tanaka: None. H. Akihama: None. E. Hasegawa: None. T. Hara: None. Y. Sato: None. S. Shimazaki: None.
- © 2014 by American Heart Association, Inc.