Abstract 246: Reduced Prehospital Survival Rate After Out-of-Hospital Cardiac Arrest in Patients with Diabetes Mellitus Type 2: A Prospective Community-Based Study
Objectives: Out-of-hospital cardiac arrest (OHCA) remains a major cause of death. We aimed to determine whether diabetes mellitus type 2 (T2DM) is associated with survival to hospital admission and to hospital discharge after OHCA.
Methods: We performed a community-based cohort study of 1549 OHCA patients with ECG-documented ventricular tachycardia/ventricular fibrillation (VT/VF). Survival to hospital admission and to hospital discharge was compared between patients with T2DM and non-DM patients using multivariate logistic regression analysis. Among discharged patients, we compared the proportions of neurologically intact (NI) survival. All analyses were stratified according to T2DM disease severity.
Results: Patients with T2DM (n=275) had lower survival rates to hospital admission than non-DM patients (n=1274, 48.7% vs. 55.8%, P=0.032). Patients with severe T2DM had lower survival rates to admission than patients with mild T2DM (37.3% vs. 53.3%, P=0.034). Multivariate analysis revealed that T2DM was an independent determinant of survival to hospital admission (OR 0.75 [95% CI 0.58-0.98]). Survival rates to hospital discharge were also lower in patients with T2DM (n=134) than in non-DM patients (n=711, 40.3% vs. 57.7%, P<0.001). Multivariate logistic regression analysis among patients admitted to hospital showed that T2DM was associated with lower survival to discharge (OR 0.57 [95% CI 0.38-0.84]). NI-status at discharge was high in both patients with T2DM and non-DM patients (94.4% vs. 94.6%, P=0.954)
Conclusion: Patients with T2DM had lower survival rates to hospital admission and to hospital discharge after OHCA than non-DM patients. T2DM was an independent determinant of lower survival.
Author Disclosures: D.A. van Hoeijen: None. M.T. Blom: None. A. Bardai: None. P.C. Souverein: None. A. de Boer: None. H.L. Tan: None.
- © 2014 by American Heart Association, Inc.