Abstract 245: Sex Difference in Clinical Outcomes in Patients with Out-of-Hospital Cardiac Arrest: SOS-KANTO 2012 Study
Background: Some studies have shown that outcome after cardiac arrest is affected by sex difference, but the influence of the difference is still not determined.
Objective: The aim of this study was to compare the favorable neurological outcome after out-of-hospital cardiac arrest (OHCA) between male and female.
Methods: The SOS-KANTO 2012 Study is a multicenter cardiac arrest registry, which contains data from 70 hospitals in Metropolitan area of Japan. Of the totally enrolled 16,452 cardiac arrests, there were 14,758 non-traumatic OHCA. Excluding 797 with do-not-attempt-resuscitation order and 2,457 with missing data, 732 patients (6.4%) of the remaining 11,504 patients who regained spontaneous circulation prior to hospital arrival were studied. Of the 732 patients, there were 488 males (67%, age: 65±16 y/o, witnessed OHCA: 79.5%, initial rhythm of VF/VT: 26.8%, presumed cardiac etiology: 55.7%, respectively) and 194 females (33%, age: 69±19 y/o, witnessed OHCA: 68.4%, initial rhythm of VF/VT: 13.1%, presumed cardiac etiology: 38.5%, respectively). The favorable neurologic outcome was defined as 1 or 2 of the cerebral performance category scale at 3 months. Chi-square and multivariate logistic regression was used to analyze the association between gender and neurological favorable outcome.
Results: The favorable neurological outcome was observed in 194 of 488 males (39.8%) and 48 of 244 females (19.7%, Chi-square test: p<0.01). The multivariate logistic regression analysis indicated that male was an independent predictor for favorable neurological outcome (adjusted odds ratio 1.95, 95%CI 1.31-2.91).
Conclusion: Our results demonstrate that men had significantly better outcome, although patient characteristics were different between male and female. Researchers studying OHCA outcomes should recognize the impact of those sex differences on the outcome.
Author Disclosures: T. Tamura: None. M. Suzuki: None. K. Hayashida: None. S. Hori: None. A. Sakurai: None. A. Yaguchi: None. N. Morimura: None. K. Nagao: None.
- © 2014 by American Heart Association, Inc.