Abstract 20652: Lifespan Predictors of Cardiovascular Morbidity in Individuals Reaching Middle Age: The Bogalusa Heart Study
Introduction: Considerable information is available on the clustering of cardiovascular (CV) risk factors across the lifespan and their impact on cardiovascular disease (CVD) morbidity and mortality. In spite of this, information is scarce on the individual contribution of CV risk factors measured longitudinally from childhood to adulthood, as well as their cumulative burden, on CVD morbidity
Methods: the longitudinal study cohort comprised 118 individuals aged 25-46 years (mean age 34.2 years); 44.1% black and 63.6% female, who were residing in the semi-rural community of Bogalusa, Louisiana and participated in the study since childhood. These participants had at least 3 traditional CV risk factors measurements since childhood and self-reported information on adult CVD morbidity. Mean follow up period was 14.3 years. CVD was defined as positive personal history of one or more of the following: angina, percutaneous coronary intervention, coronary artery bypass grafting, myocardial infarction and/or stroke. The area under the curve (AUC) was used to assess the cumulative burden of risk factors.
Results: after accounting for the effect of age, race, sex, cigarette smoking and family history of CVD, significant predictors of CVD were: childhood body mass index (BMI) (Odds Ratio [OR], 1.36; 95% Confidence Interval [95% CI] 1.12-1.62) and non-high density lipoprotein cholesterol (nonHDL-C) (OR, 1.22; 95% CI, 1.15-1.73); adulthood BMI (OR, 1.13; 95%CI, 1.02-1.24), Systolic Blood Pressure (SBP) (OR, 1.32; 95%CI, 1.07-1.65) and nonHDL-C (OR, 1.39; 95%CI, 1.11-1.56); and long-term cumulative burden of BMI (OR, 1.29; 95%CI, 1.21-1.37) and nonHDL-C (OR, 1.47; 95%CI, 1.38-1.71)
Conclusions: the observed adverse associations of childhood / adulthood cardiovascular risk factors and their long-term cumulative burden on adult CVD morbidity, are indicative of the individual impact of these risk factors in the development of heart disease. Hence, risk factor-oriented interventions (through primordial prevention early in life) must continue to be implemented to avoid further deleterious effects caused by risk factors and subsequent disease complications.
Author Disclosures: C. Fernández Alonso: None. S. Li: None. R. Blandon: None. W. Chen: None. S.R. Srinivasan: None. G.S. Berenson: None.
This research has received full or partial funding support from the American Heart Association.
- © 2014 by American Heart Association, Inc.