Abstract 20393: Association Between Long-Term Alcohol Intake and Arterial Stiffness in Middle Aged Japanese Men
Introduction: Alcohol intake has been reported to be associated with a dose-related increase in blood pressure. Increased arterial stiffness has been also reported to be associated with increased blood pressure. However, conflicting results have been reported on the long term relationship between alcohol intake and arterial stiffness.
Hypothesis: Whether there is significant association between long term alcohol intake and arterial stiffness.
Methods: Middle aged Japanese men who underwent annual health screening check were prospectively followed up to 12 years from 2000. Arterial stiffness was annually measured as brachial-ankle pulse wave velocity (PWV), and daily alcohol intake was assessed by self reported questionnaire. We excluded those with missing data for PWV or alcohol intake, and those with an ankle/brachial systolic blood pressure index (ABI) of <0.95, atrial fibrillation, and undergoing regular hemodialysis. As a result, a total 3119 subjects (mean age at baseline; 40.7 years) with available follow-up PWV and alcohol intake were included. We performed linear mixed models to examine longitudinal changes in PWV and daily alcohol intake over 12 years. Linear mixed model was adjusted for conventional risk factor for increased PWV. We considered overall findings plus those stratified by baseline blood pressure level.
Results: The annual increase in PWV was positively associated with daily alcohol intake. Annual 10g/day alcohol intake was associated with 0.47 cm/sec higher PWV (p<0.05). In secondary analyses stratified by baseline blood pressure level, both subjects with normal blood pressure (SBP<130mmHg) and those with raised blood pressure (SBP≥130mmHg or subjects with anti-hypertensive medication) showed significant association of annual increase in PWV and daily alcohol intake. Annual 10g/day alcohol intake was associated with 0.29 cm/sec higher PWV in subjects with normal blood pressure and corresponding value in those with raised blood pressure were 0.67 cm/sec (both p<0.05).
Conclusions: In middle aged Japanese men, increased annual alcohol intake was associated with higher PWV. Especially, this potential associated appeared to be stronger among men with raised blood pressure.
Author Disclosures: C. Matsumoto: None. H. Tomiyama: None. K. Kimura: None. M. Odaira: None. K. Shiina: None. A. Yamashina: None.
- © 2014 by American Heart Association, Inc.